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- Linked reaction between blood vessels and nervesInstead, the cause of a brain freeze is a linked reaction between blood vessels and nerves. The bundle of nerves in this part of the mouth senses something cold and sends an instant message to the brain, causing arteries and blood vessels to react. As a result, your head starts to throb. The ache also comes on fast.www.health.com/condition/headaches-and-migraines/what-is-brain-freeze
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