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- Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.Cells (or in vitro cell cultures) that will grow, survive, or maintain function only when attached to an inert surface such as glass or plastic; also known as substrate-dependent cells. The only normal animal cells that are designed to survive without attachment and spreading are cells that circulate in the blood.www.oxfordreference.com/display/10.1093/oi/autho…
The phenomenon exhibited by many normal cells in culture which require attachment to a solid substratum in order to spread and grow. Spreading may be necessary in order to absorb rate-limiting growth factors from the culture medium.
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