what causes restless legs at night - Search
    • The exact cause is not known
    • Family history - it is believed to be hereditary
    • Abnormalities in the brain can lead to this condition
    • Neurotransmitters (chemicals that help to transmit signal to the brain) abnormalities can cause this problem
    • The conditions which are likely to cause restless leg syndrome include
    • The iron deficiency anemia
    • Peripheral neuropathy - damage to the nerves of limbs due to underlying conditions such as diabetes
    • Parkinson's disease
    • Varicose veins
    • Fibromyalgia
    • Hyper- or hypothyroidism (over- or underactive thyroid glands)
    • Severe kidney disease and uremia (kidney failure causing build up of toxins within the body)
    • Amyloidosis (build-up of a starch-like substance in the body's tissues and organs)
    • Lyme disease
    • Damage to spinal nerves
    • Rheumatoid arthritis
    • Sjögren syndrome
    • Pregnancy

    See more

    Complications

    Verified Expert

    It doesn’t usually cause complications. Quality of life is affected in severe cases.

    See more

    Symptoms

    Verified Expert
    Contact your provider if experiencing new, severe, or persistent symptoms.

    The major symptom is urging to move your legs, especially after rest and worsens in the evening. The other symptoms include:

    • Tingling, burning or itching
    • A creepy-crawly feeling
    • Feeling like fizzy water is inside the blood vessels in the legs
    • A painful, cramping sensation in the legs, particularly in the calves
    • Leg jerking
    • Pulling - feeling of pulling in the legs
    • Throbbing - sensation of throbbing near the calves
    • Aching- leg pain

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    Diagnosis

    Verified Expert
    One or more of these tests may be recommended by your medical provider.
    The condition is usually self-diagnosable and tests are usually required to rule out any other condition with similar symptoms.

    Common tests & procedures

    Polysomnography: In certain cases polysomnography (sleep study, to check the leg movement during sleep) may be done.

    Electromyography (EMG): To detect the leg movements during sleep.

    Iron deficiency test: To check for iron deficiency.

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    Treatment

    Verified Expert

    Treatment involves managing the underlying conditions.

    Medication

    Iron Replacement: Iron replacement is suggested whose fasting serum ferritin levels are < 75 micrograms/litre. Usually recommended when the condition is secondary to iron deficiency anemia.

    Ferrous sulphate . Ferric carboxymaltose

    Antidepressants: To reduce the symptoms of depression, which may result to disturbed sleep pattern.

    Buproprion . Ropinirole . Rotigotine . Pramipexole

    Calcium channel regulators: Work for some chronic, persistent cases. Usually recommended in some cases.

    Gabapentin . Pregabalin

    Narcotic medication: Usually addictive and are used if other drugs do not work. Usually recommended in some cases.

    Oxycodone . Hydrocodone

    Sedatives: To help sleep better.

    Clonazepam . Eszopiclone . Temazepam

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  2. Possible causes and triggers of restless legs at night include12345:
    • Low levels of iron in the brain
    • Imbalance of dopamine
    • Genetic component (about 60% of people with RLS have a family member with the condition)
    • Nerve damage in the legs from diabetes, kidney problems, or other health conditions
    • Certain medications
    • Stress
    • Alcohol, caffeine, and nicotine
    • Pregnancy or hormonal changes
    • Sleep deprivation or sleep disorders
    Learn more:
    Experts believe that low levels of iron in the brain may be responsible for RLS. An imbalance of dopamine is also believed to contribute. About 60% of people with restless legs have a family member with the condition, indicating a strong genetic component.
    www.helpguide.org/wellness/sleep/restless-leg-syn…
    The cause of RLS is still unknown. Some cases are believed to be inherited. Some cases have been linked with nerve damage in the legs from diabetes, kidney problems, iron deficiency, certain medicines, pregnancy, sleep disorders, and alcoholism.
    www.hopkinsmedicine.org/health/conditions-and-di…
    Triggers are things that make your RLS symptoms worse. Possible triggers can vary but could include: Alcohol. Caffeine. Nicotine. Certain medications. Stress. If you experience these triggers or use/take them before you rest or go to bed, they’re more likely to set off your symptoms.
    my.clevelandclinic.org/health/diseases/9497-restle…
    If you're experiencing restless legs at night, a variety of factors could be contributing to your symptoms. Having underlying health conditions, eating certain foods, or being pregnant may all lead to the onset of restless legs.
    www.health.com/restless-legs-causes-7972584

    RLS also appears to be related to or accompany the following factors or underlying conditions:

    • End-stage renal disease and hemodialysis
    • Neuropathy (nerve damage)
    • Sleep deprivation and other sleep conditions such as sleep apnea
    www.ninds.nih.gov/health-information/disorders/res…
     
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