Gugino was born in Sarasota, Florida, to Carl Gugino, an orthodontist of Italian descent, and Susan Gugino, a mother of English and Irish descent described as "Bohemian". Her parents separated when she was tw… See more

Gugino's television work during the late 1980s and early 1990s included appearances on Good Morning, Miss Bliss, Saved by the Bell, Who's the Boss?, ALF, Doogie Howser, M.D., The Wonder Years, Webster and … See more

In 1996, Gugino began a relationship with her collaborator, Sebastián Gutiérrez. Gugino stated in 2009 that they had no plans to marry: "Marriage isn't important for us. We like being boyfriend and girlfriend; there's som… See more