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See all on WikipediaAntisense therapy - Wikipedia
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content … See more
The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense … See more
Half-life and stability
ASO-based drugs employ highly modified, single-stranded chains of synthetic nucleic acids that … See moreCurrent clinical trials
As of 2020 more than 50 antisense oligonucleotides were in clinical trials, including over 25 in See moreAugust 1998Fomivirsen was approved by the U.S. FDA as a treatment for cytomegalovirus retinitis.January 2013Mipomersen was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.December 2016Nusinersen received regulatory approval from FDA and soon after, from other regulatory agencies worldwide.May 2019Volanesorsen was approved by the European Medicines Agency for the treatment of familial chylomicronaemia syndrome.October 2018Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis.2019Milasen was approved by the FDA for the treatment of Batten disease.2020Eteplirsen, golodirsen, and viltolarsen received FDA approval for the treatment of cases that can benefit from skipping exon 51 or 53 of the dystrophin transcript.2023Tofersen was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis
Tofersen (marketed as Qalsody) was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis See moreWikipedia text under CC-BY-SA license Antisense technology: an overview and prospectus - Nature
WebMar 24, 2021 · Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use,...
- Author: Stanley T Crooke, Brenda F Baker, Rosanne M Crooke, Xue-Hai Liang
- Publish Year: 2021
Antisense - National Human Genome Research Institute
WebMay 9, 2024 · Antisense is the non-coding DNA strand of a gene. In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. Narration. Antisense. …
- Studies of Antisense wikipedia
Antisense technology: A review - Journal of Biological …
WebXue-Hai Liang. Brenda F. Baker. Rosanne M. Crooke. Open Access Published: February 15, 2021 DOI: …
- Author: Stanley T. Crooke, Xue-Hai Liang, Brenda F. Baker, Rosanne M. Crooke
- Publish Year: 2021
Antisense technology: an overview and prospectus - PubMed
WebAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have …
WebMar 24, 2021 · Antisense technology is a drug discovery platform based on short chemically modified oligonucleo-tides (12–24-mers) that bind to their RNA targets by Watson–Crick base pairing10–13. Before ...
Antisense oligonucleotides: the next frontier for …
WebDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein expression through several distinct...
Antisense Therapy in Neurology - PMC - National Center for ...
WebAug 2, 2013 · Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged as an exciting and promising strategy for the treatment of various neurodegenerative and …
Antisense RNA: the new favorite in genetic research - PMC
WebDec 6, 2017 · Antisense RNAs represent a specific type of ncRNA used for regulating genetic activity at multiple levels in cells, such as at DNA, RNA and chromosome structures, transcription and translation, and RNA and protein stabilities (Rusk, …
The powerful world of antisense oligonucleotides: …
WebMar 31, 2020 · Abstract. Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the …
Antisense Oligonucleotides: An Emerging Area in Drug Discovery …
WebJun 26, 2020 · Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO field is an emerging area of drug development that targets the disease source at the RNA …
Antisense technology: A review - ScienceDirect
WebJan 1, 2021 · “Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is used to refer to ss ASOs, and siRNA refers to ds ASOs that act via AGO2 to cause …
Antisense therapy for cancer | Nature Reviews Cancer
WebMay 20, 2005 · An antisense oligonucleotide (ASO) is a single-stranded, chemically modified DNA-like molecule that is 17–22 nucleotides in length and designed to be complementary to a selected gene's mRNA and...
Antisense Therapy - an overview | ScienceDirect Topics
WebAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single-stranded DNA sequences engineered to be complementary to the specific ‘sense’ (5' to …
Antisense RNA Therapeutics: A Brief Overview. - PMC
WebNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS-CoV-2. Another type of nucleic acid therapeutics is antisense oligonucleotides, versatile tools …
Oblimersen - Wikipedia
WebOblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense oligodeoxyribonucleotide being studied as a possible treatment for several types of cancer, including chronic lymphocytic leukemia, B …
Antisense technology as a potential strategy for the treatment of ...
WebMar 10, 2022 · Antisense technology as a potential strategy for the treatment of coronaviruses infection: With focus on COVID‐19 - PMC. Journal List. IET Nanobiotechnol. v.16 (3); 2022 May. PMC9007150. As a library, NLM provides access to scientific literature.
The Application of Antisense Technology to Medicine - PMC
WebAntisense technology is a formidable tool for investigating physiologic and pathologic processes. In addition, it is soon likely to become a mainstay of therapy, particularly in infectious diseases, with wider applications in the future as gene therapy techniques are …
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