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See all on WikipediaAntisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content … See more
The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense oligonucleotides. See more
Half-life and stability
ASO-based drugs employ highly modified, single-stranded chains of synthetic nucleic acids that … See moreCurrent clinical trials
As of 2020 more than 50 antisense oligonucleotides were in clinical trials, including over 25 in See moreAugust 1998Fomivirsen was approved by the U.S. FDA as a treatment for cytomegalovirus retinitis.January 2013Mipomersen was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.December 2016Nusinersen received regulatory approval from FDA and soon after, from other regulatory agencies worldwide.May 2019Volanesorsen was approved by the European Medicines Agency for the treatment of familial chylomicronaemia syndrome.October 2018Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis.2019Milasen was approved by the FDA for the treatment of Batten disease.2020Eteplirsen, golodirsen, and viltolarsen received FDA approval for the treatment of cases that can benefit from skipping exon 51 or 53 of the dystrophin transcript.2023Tofersen was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis
Tofersen (marketed as Qalsody) was approved by the FDA for the treatment of SOD1- associated See moreWikipedia text under CC-BY-SA license WebMar 24, 2021 · Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have …
- Author: Stanley T Crooke, Brenda F Baker, Rosanne M Crooke, Xue-Hai Liang
- Publish Year: 2021
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WebAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs …
WebDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein expression through several distinct...
WebMar 24, 2021 · Antisense technology is a drug discovery platform based on short chemically modified oligonucleo-tides (12–24-mers) that bind to their RNA targets by Watson–Crick …
WebXue-Hai Liang. Brenda F. Baker. Rosanne M. Crooke. Open Access Published: February 15, 2021 DOI: https://doi.org/10.1016/j.jbc.2021.100416. Antisense technology: A review. Antisense technology is beginning to …
WebAug 2, 2013 · Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged …
WebMay 9, 2024 · Antisense is the non-coding DNA strand of a gene. In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. Narration. Antisense. …
WebDec 6, 2017 · Antisense RNAs represent a specific type of ncRNA used for regulating genetic activity at multiple levels in cells, such as at DNA, RNA and chromosome …
Antisense RNA Therapeutics: A Brief Overview. - PMC
WebNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS …
Oblimersen - Wikipedia
WebOblimersen (INN, trade name Genasense; also known as Augmerosen and bcl-2 antisense oligodeoxynucleotide G3139) is an antisense oligodeoxyribonucleotide being studied as …
Gene regulation by antisense transcription | Nature Reviews …
WebNov 12, 2013 · Antisense expression can coordinate gene expression either in cis or in trans. Their ability to interact with other regulatory mechanisms emphasizes their …
Antisense Therapy - an overview | ScienceDirect Topics
WebAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single …
The powerful world of antisense oligonucleotides: …
WebMar 31, 2020 · Abstract. Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the …
Antisense therapy for cancer | Nature Reviews Cancer
WebMay 20, 2005 · An antisense oligonucleotide (ASO) is a single-stranded, chemically modified DNA-like molecule that is 17–22 nucleotides in length and designed to be …
Antisense Drugs Make Sense for Neurological Diseases - PMC
WebJan 1, 2021 · A new class of drugs - antisense oligonucleotides (ASOs) - are showing promise as a therapeutic platform for treating neurological diseases. ASOs are designed …
Antisense technology as a potential strategy for the treatment of ...
WebMar 10, 2022 · Antisense technology as a potential strategy for the treatment of coronaviruses infection: With focus on COVID‐19 - PMC. Journal List. IET …
The Application of Antisense Technology to Medicine - PMC
WebAntisense technology is a formidable tool for investigating physiologic and pathologic processes. In addition, it is soon likely to become a mainstay of therapy, particularly in …
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