• It is caused due to inheritance of defective gene.
• Type I hemochromatosis is caused by defects (mutations) in the HFE gene which has many purposes, but an important role is to control the amount of iron that is absorbed from food.
• There are several known mutations in the HFE gene, but presently testing for only three is available: C282Y, H63D, and S65C.
• Disruption of the hormone hepcidin which is secreted by the liver and responsible to control the iron absorption would also lead to hemochromatosis.
• Autoimmunity in a neonate can also be a cause of hemochromatosis in kids.
• Multiple blood transfusion in people suffering with severe cases of anemia might also lead to hemochromatosis.

• As this is a hereditary disorder, it cannot be prevented
• Identifying early and treating can help avoid complications

If untreated for a prolonged period it may lead to

Liver problems:

• Cirrhosis – permanent scaring of the liver tissue

Pancreas problems

• Damage to the pancreases, which can lead to diabetes

Heart problems

• Excess iron in the heart affects its ability to circulate enough blood.
• It can also cause abnormal heart rhythms

Reproductive problems

• Excess iron can cause erectile dysfunction

Skin color changes

• Excess iron can cause skin color change to brown or grey

It can be treated effectively by removing blood to reduce the iron level. The condition cannot be cured.

Medication

Chelation therapy: Administration of drugs to expel excess iron in the blood (for those with heart disease, anemia or poor venous access).

Deferoxamine . Deferasirox . Deferiprone . Iron-binding dendrimers