The expression “bite me” originates from American college campuses in the 1980s. According to the Green’s Dictionary of Slang, “bite me!” has the same meaning as “bite me in the ass.” The dictionary states it labels it an exclamation of a generally dismissive or derogatory nature.

Bite me is typically used as a US idiomatic expression of discontent or annoyance with another party a command, similar to "Go to hell!" (i.e. "Leave me alone!" "Go away!" etc.) Note: not considered especially vulgar, but usually considered inappropriate in more formal settings.