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- Read-across is a method used in chemical risk assessment to predict the properties of a substance based on the properties of a similar substance123.Examples of read-across include123:
- Qualitative read-across, which is a yes or no indication as to whether the target substance is expected to elicit a particular effect, as observed with the analogue(s).
- Quantitative read-across, which obtains a numerical value for a particular property or endpoint based on information available for the analogue(s).
- Serial registration in China, where read-across is widely used. Enterprises shall provide physicochemical data of each substance as well as a complete set of data that consists of health toxicological data and eco-toxicological data of new substances in the group.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.For example, qualitative read-across could be a yes or no indication as to whether the target substance is expected to elicit a particular effect, as observed with the analogue (s). With quantitative read-across, a numerical value is obtained for a particular property or endpoint based on information available for the analogue (s).www.canada.ca/en/health-canada/services/chemic…Take new substance registration in China for example, read-across is widely used in serial registration. When carrying out serial registration, enterprises shall provide physicochemical data of each substance as well as a complete set of data that consists of health toxicological data and eco-toxicological data of new substances in the group.www.cirs-group.com/en/chemicals/interpretation-o…Example for an identity of the source substance which is clear and unambiguous and allows a meaningful read-across assessment A mono-constituent substance consists of 97.0-99.5% (typical 99.0%) Substance A and 0.5- 3.0% identified impurities5 (typical 1.0% water).www.echa.europa.eu/documents/10162/17221/raaf… - People also ask
READ ACROSS definition and meaning | Collins English Dictionary
Web5 days ago · read across. If you read across from one thing to another, you think or conclude that what is true of the first thing is also true of the second thing. It is dangerous to read across from one bank to the whole sector. [VP from n to n] There are some …
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Introduction to Read-across: Principles, Techniques and …
WebJul 29, 2022 · This presentation will provide an overview of common principles and techniques employed in read-across, outlining available frameworks and guidelines for …
READ-ACROSS Definition & Meaning | Dictionary.com
Webnoun. a correlation or relationship between two separate things. Discover More. Example Sentences. Shock at what the government considers dangerous and high risk could be …
- Studies of read across example
- Whenever category approach read-across is used, properties of a target substance are predicted from properties of source substances within the category. The category hypothesis should apply in an unambiguous manner to all the category members. Only category members that are covered by the category hypothesis can be involved in the read-across. This...
Read-Across Methodology in Toxicological Risk Assessment
WebJun 19, 2021 · Abstract. Grouping approaches like read-across (RAx) are one of the most widely used methods to fill data gaps in human risk assessment. In a RAx approach, in …
Chemical Safety Assessment Using Read-Across: Assessing the …
WebMay 8, 2015 · The aim of the suggested strategy for chemical read-across is to show how a traditional read-across based on structural similarities between source and target …
Examples of 'read-across' in a sentence - Collins Online Dictionary
WebExamples of 'read-across' in a sentence. Examples from Collins dictionaries. It is dangerous to read across from one bank to the whole sector. There are some structural …
Overview on guidance documents and read-across workflows
WebNov 28, 2019 · This paper will first give a very brief overview on the current read-across guidances and will point to typical challenges in a read-across assessment using …
Navigating through the minefield of read-across tools: A review of …
WebAn OECD work programme under the auspices of the Task Force of Hazard Assessment (TFHA) 1 has published several examples of AOP informed Integrated Approaches to …
WebThis illustrative example puts forward a read- across hypothesis developed between two structurally similar substances based on the similarity of their breakdown products. This …
Navigating through the minefield of read-across frameworks: A ...
WebMay 1, 2018 · Abstract. Read-across is a popular data gap filling technique used within analogue and category approaches for both regulatory and product stewardship purposes.
Exploring Current Read-across Applications and Needs Among …
WebRead-across is also relied upon within internal company product stewardship processes (Wu et al., (2010) is an example). The approach gained significant attention in the run up …
Grouping of substances and read-across - ECHA
WebECHA has developed an illustrative example of a grouping of substances and read-across approach to support companies in complying with their obligations under REACH. The …
WebIn the near future, illustrative examples for broad public access could be prepared. Introduction. Read-across has garnered much attention, since it may be used as an …
Introduction to Read-across: Principles, Techniques and …
WebJul 29, 2022 · Overview. Read-across is a popular methodology that allows predictions to be made for a variety of endpoints using experimental data from a source analogue (s) …
Towards systematic read-across using Generalised Read-Across …
WebFeb 1, 2023 · A practical guide to using and interpreting the GenRA web app is discussed with an example. •. Next steps and future directions of GenRA are described. Abstract. …
An End Point-Specific Framework for Read-Across Analog …
WebDec 2, 2022 · An example of a Tier II read-across for isopropyl propionate is isopropyl decanoate; even though the functional groups are the same, the difference in the number …
Interpretation on How to Properly Adopt Read-across Approach …
WebApr 20, 2022 · As one of the most frequently used alternative methods for hazard assessment, the read-across approach has been widely adopted in chemical …
Meaning of "read-across" in the English dictionary - educalingo
Web«Read-Across» Meaning of read-across in the English dictionary with examples of use. Synonyms for read-across and translation of read-across to 25 languages.
Metabolomics as read-across tool: An example with 3 …
WebNov 1, 2019 · •. A read across from 2-aminoethanol (MEA) to 3-aminopropanol (3AP) is presented. •. Metabolomics is used to add biological information to support the read …
Read-across example - ECHA - Europa - Yumpu
WebJul 29, 2013 · Example 1<br /> <strong>Read</strong>-<strong>across</strong> illustrative <strong>example</strong><br /> DISCLAIMER<br /> This document …
WebStep-by-step example for predicting Ames mutagenicity by making use of read-across. Background. Keywords. Objectives. Specific Aims. Read-across. The exercise. …
What do 'Read Across', 'Drill Deep' & '6 Panels' mean in GM's …
WebJun 7, 2011 · Read across is sheet to complete to verify that you have considered if this defect or root cause of the a defect can impact any other similar part or manufacturing …
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