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  2. Taking this into account, the study demonstrates the more persistent therapeutic effects of a single administration of psilocybin compared to ketamine and supports the idea that serotonin 5-HT 2A receptor directed therapeutic strategies may be superior to ketamine-based treatments in the clinic for depression.
    psychedelicreview.com/psilocybin-demonstrates-a …
    Two studies found that treatment with COMP360 psilocybin therapy reduced depression symptoms in patients with treatment-resistant depression, and a third study found that using precision medicine for ketamine dosing may decrease the high efficacy-low effectiveness gap in the management of treatment-resistant depression.
    www.clinicaladvisor.com/home/topics/psychiatry-inf…
     
  3. People also ask
    Are psilocybin and ketamine safe for treatment of depression?Ketamine also has significant abuse liability, and there are certain safety issues associated with its long-term use. Therefore, it is important to determine comparative efficacy of psilocybin and ketamine toward developing safe and effective therapeutic strategies in the clinic for the treatment of depression.
    Does psilocybin and ketamine affect neurotransmitters' release?The effect of psilocybin and ketamine on neurotransmitters’ release was never studied in detail, but by a direct comparison of their impact on the neuronal network the mechanism of psychedelics in the brain may be explained.
    Can psilocybin help with depression?A 2020 clinical trial found that two doses of psilocybin alongside talk therapy significantly reduced depression symptoms for at least 4 weeks after therapy. A 2020 review of trials suggests that psilocybin is safe enough to consider as a first-line treatment for both depression and anxiety.
    Can ketamine and psilocybin be used as fast-acting antidepressants?Int J Mol Sci. 2022 Jun; 23 (12): 6713. Clinical studies provide evidence that ketamine and psilocybin could be used as fast-acting antidepressants, though their mechanisms and toxicity are still not fully understood.
     
  4. Ketamine vs. Psilocybin for Therapy - Field Trip Health

     
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