1560s, "something made by hand," from French manufacture (16c.), from Medieval Latin *manufactura "a making by hand" (source of Italian manifattura, Spanish manufactura), from Latin manu, ablative of manus "hand" (from PIE root *man- (2) "hand") + factura "a working," from past-participle stem of facere "to perform" (from PIE root *dhe- "to set, put").

from early French manufacture "something made," from Latin manufactus "made by hand," from earlier manu "by hand" (from manus "hand") and factus, past participle of facere "to make, do" — related to factory, fashion, manage, manual

manufacture Etymology [ edit] From Middle French manufacture, from Old French, from Medieval Latin manūfactūra (“a making by hand”), from manūfactus, a compound of manū factus, manū being ablative of manus (“hand”), and factus past participle of faciō (“I do, make”).

First recorded in 1560–70; from Middle French manufacture “the action or process of making; a factory,” equivalent to Latin manū “by hand”, ablative singular of manus “hand” + Middle French facture “making, construction” (from Late Latin factūra “action of creating, a creation, piece of handiwork,” from Latin factūra “act of fashioning; metal working,” a derivative of facere “to make, do”); the verb is derivative of the noun