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  2. How they’re made

    The key difference between them is how they’re made: Opiates are naturally occurring compounds, while opioids are either fully or partially synthetic (made by humans). That said, many people use the term “opioids” to refer to all opiates and opioids.
    www.healthline.com/health/opiate-vs-opioid
    www.healthline.com/health/opiate-vs-opioid
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