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Spherical nucleic acids- According to 4 sources
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See all on WikipediaSpherical nucleic acid - Wikipedia
Spherical nucleic acids (SNAs) are nanostructures that consist of a densely packed, highly oriented arrangement of linear nucleic acids in a three-dimensional, spherical geometry. This novel three-dimensional architecture is responsible for many of the SNA's novel chemical, biological, and … See more
The SNA structure typically consists of two components: a nanoparticle core and a nucleic acid shell. The nucleic acid shell is made up of short, synthetic oligonucleotides terminated with a functional group … See more
Intracellular gene regulation
SNAs are being proposed as therapeutic materials. Despite their high negative charge, they are taken up by cells (also negatively charged) … See moreThe economic impact of SNA technology is substantial. Three companies have been founded that are based on SNA technology – … See more
Wikipedia text under CC-BY-SA license Gene Regulation Using Spherical Nucleic Acids to Treat Skin …
WEBNov 2, 2020 · In this review we: (i) describe the production, structure and properties of SNAs; (ii) detail the mechanism of SNA uptake in keratinocytes, regulated by scavenger …
- Author: Thomas R Holmes, Amy S Paller
- DOI: 10.3390/ph13110360
- Publish Year: 2020
- Published: 2020/11
Molecular spherical nucleic acids | PNAS
WEBSignificance. Spherical nucleic acids (SNAs) made thus far are inherently polydisperse due to variations in surface nucleic acid density, particle size, or both. In this article, we …
Molecular spherical nucleic acids - PMC - National Center for ...
WEBApr 4, 2018 · Significance. Spherical nucleic acids (SNAs) made thus far are inherently polydisperse due to variations in surface nucleic acid density, particle size, or both. In …
- Author: Hui Li, Bohan Zhang, Xueguang Lu, Xuyu Tan, Fei Jia, Yue Xiao, Zehong Cheng, Yang Li, Dagoberto O. S...
- DOI: 10.1073/pnas.1801836115
- Publish Year: 2018
- Published: 2018/04/04
Spherical nucleic acids: A whole new ball game - PMC
WEBAug 8, 2013 · Mirkin’s spherical nucleic acids (SNAs) are built from multiple strands of DNA, all dangling from a common center like the woolen threads of a pom-pom. …
- Author: Sarah C. P. Williams
- DOI: 10.1073/pnas.1313483110
- Publish Year: 2013
- Published: 2013/08/08
Spherical nucleic acids: Organized nucleotide aggregates as
WEBAbstract. Spherical nucleic acids (SNAs) are composed of a nanoparticle core and a layer of densely arranged oligonucleotide shells. After the first report of SNA by Mirkin and …
Spherical nucleic acids: Organized nucleotide …
WEBSpherical nucleic acids (SNAs) are composed of a nanoparticle core and a layer of densely arranged oligonucleotide shells. After the first report of SNA by Mirkin and coworkers in 1996, it has created a significant interest by …
Mechanism for the endocytosis of spherical nucleic acid ... - PNAS
WEBApr 23, 2013 · Spherical nucleic acids (SNAs) represent an emerging class of nucleic acids distinct from linear nucleic acids in the context of gene regulation ( 1, 2 ). …
Enhancing Endosomal Escape and Gene Regulation Activity for …
WEBNov 6, 2023 · When formulated as spherical nucleic acids (SNAs), siRNAs are resistant to nuclease degradation and enter cells without transfection agents with enhanced activity …
Inspired Beyond Nature: Three Decades of Spherical Nucleic …
WEBAug 16, 2023 · Roughly a decade later, we would come to realize that this arrangement of DNA (or RNA) around a nanoscale spherical template defined an entire new form of …
Spherical Nucleic Acids as Precision Therapeutics for the
WEBMar 23, 2022 · Spherical Nucleic Acids (SNAs) emerged as a new class of nanotherapeutics consisting of a nanoparticle core densely functionalized with a shell of …
Biochemistry and biomedical applications of spherical nucleic …
WEBIn this chapter, we describe a novel three-dimensional nucleic acid architecture, referred to as the spherical nucleic acid (SNA), which possesses a number of exceptional …
Therapeutic applications of spherical nucleic acids - PubMed
WEBSpherical nucleic acids (SNAs) represent an emerging class of nanoparticle-based therapeutics. SNAs consist of densely functionalized and highly oriented …
WEBAug 15, 2023 · Spherical nucleic acids (SNAs) are composed of a nanoparticle core and a layer of densely arranged oligonucleotide shells. After the first report of SNA by …
Tracking endocytosis and intracellular distribution of ... - Nature
WEBDec 7, 2020 · Traceable spherical nucleic acids (SNAs) are fabricated by decorating 50-nm spherical gold NPs with fluorophore-labeled DNA, serving as dually emissive …
The effector mechanism of siRNA spherical nucleic acids - PMC
WEBJan 1, 2020 · Abstract. Spherical nucleic acids (SNAs) are nanostructures formed by chemically conjugating short linear strands of oligonucleotides to a nanoparticle template.
Nanomedicine - Mirkin
WEBWhat are SNAs? Spherical nucleic acids, or SNAs, (Fig. 1) are three-dimensional nanostructures, consisting of nucleic acids that are densely functionalized and oriented …
Rational vaccinology maximizes the efficacy of multi-antigen
WEBJan 30, 2023 · Spherical nucleic acids (SNAs), composed of a nanoparticle core with a dense radial shell of immunostimulatory oligonucleotides, were invented and developed …
Spherical nucleic acids-based biosensors for cancer biomarkers ...
WEBDec 1, 2022 · Spherical nucleic acids (SNAs) are three-dimensional and polyvalent nanostructures with highly oriented and densely arranged nucleic acids shell attached to …
Design Considerations for RNA Spherical Nucleic Acids (SNAs)
WEBSep 9, 2016 · Spherical nucleic acids (SNAs) are an emerging class of nanomaterials that consist of nanoparticle cores densely functionalized with shells of oriented …
Design Considerations for RNA Spherical Nucleic Acids (SNAs)
WEBSpherical nucleic acids (SNAs) are an emerging class of nanomaterials that consist of nanoparticle cores densely functionalized with shells of oriented oligonucleotides. 1 …
WEBSpherical nucleic acids (SNAs) made thus far are inherently polydisperse due to variations in surface nucleic acid density, particle size, or both. In this article, we describe the …
A modular RNA delivery system comprising spherical nucleic …
WEBNucleic acid cargoes or nucleic acid-tagged targeting moieties can be attached by hybridization to the coronal DNA. These polymeric SNAs are used to deliver siRNA …
Optimized Lipid Nanoparticles (LNPs) for Organ-Selective Nucleic …
WEB6 days ago · Nucleic acid therapeutics offer tremendous promise for addressing a wide range of common public health conditions. ... the development of spherical nucleic …
WEBnucleic acids (SNAs) represent an emerging class of nucleic acids distinct from linear nucleic acids in the context of gene regulation (1, 2). These nanostructures, although …
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