Leoni was born on February 25, 1966, in New York City. Her mother, Emily Ann (née Patterson), was a dietitian and nutritionist, and her father, Anthony Pantaleoni, was a corporate lawyer with the firm See more

In 1988, Leoni was cast as one of the stars of Angels 88, an updated version of the 1970s show Charlie's Angels. After production delays, the show never aired. The following year, she was cast as Lisa … See more

Leoni married Neil Joseph Tardio Jr., a television commercial producer, on June 8, 1991, at St. Luke's Episcopal Church in Hope Township, New Jersey. They divorced in 1995.
Leoni married actor David Duchovny on May 13, 1997, after … See more

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