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- Nicotinamide is generally well-tolerated. It's known to be safe in doses of 35 mg or less, and possibly safe in doses of 900-1500 mg daily. When taken in high doses over three grams (3,000 mg) per day, nicotinamide can cause serious side effects such as nausea, vomiting, and liver issues. Also, nicotinamide isn't safe for everyone.www.health.com/nicotinamide-benefits-7561633
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