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- Epididymitis (pronounced e-pe-di-de-mi-tis) is a medical term for swelling and irritation of your epididymis, a tube at the back of your testicle that carries sperm. This condition causes pain and swelling in your testicle. Usually, epididymitis develops from a sexually transmitted infection (STI) or from a bacterial or viral infection.my.clevelandclinic.org/health/symptoms/22518-swollen-testicles-scrotal-swelling
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