How Paneth Cells Protect Against Bacterial ThreatsThe Gut's Secret Defenders
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Paneth cells as the cornerstones of intestinal and organismal …
WebDec 27, 2022 · Paneth cells are the main producers of AMPs in the gastrointestinal tract, making them key players in sensing and controlling the microbiome composition. …
- DOI: 10.15252/emmm.202216427
- Published: 2023/02
- Publication: EMBO Mol Med. 2023 Feb; 15(2): e16427.
Paneth cells in intestinal physiology and pathophysiology
WebNov 11, 2017 · The review provides an overview of the key points of Paneth cell activities in intestinal physiology and pathophysiology. Keywords: Antimicrobial peptide, Paneth cell, …
- Author: Nikolaus Gassler
- DOI: 10.4291/wjgp.v8.i4.150
- Publish Year: 2017
- Published: 2017/11/11
Frontiers | The Paneth Cell: The Curator and Defender of the …
WebApr 2, 2020 · Paneth cells are secretory epithelial cells that produce antimicrobial peptides and immunomodulators in the small intestine. They are essential for …
Paneth cells and their multiple functions - PubMed
WebThis review aims to address the main characteristics of Paneth cells, highlighting their multiple functions and the importance of their preservation to ensure bowel homeostasis. …
Paneth cells, antimicrobial peptides and maintenance of ... - Nature
WebMar 22, 2011 · The Paneth cells in the endothelium of the small intestine produce a large array of antimicrobial proteins that help set this balance and protect the host from …
Paneth cells as the cornerstones of intestinal and organismal …
WebDec 27, 2022 · Paneth cells are secretory cells located in the crypts of Lieberkühn, adjacent to the intestinal stem cells. They produce antimicrobial peptides and proteins and other …
The Paneth Cell: The Curator and Defender of the Immature …
WebApr 3, 2020 · This review will provide an up to date and comprehensive look at Paneth cell ontogeny, the impact Paneth cells have on the host-microbial axis in the immature …
Paneth’s cell | Gastric Mucosa, Intestinal Crypts
WebPaneth’s cell, specialized type of epithelial cell found in the mucous-membrane lining of the small intestine and of the appendix, at the base of tubelike depressions known as Lieberkühn glands. Named for the 19th …
Paneth cells as the cornerstones of intestinal and organismal …
WebDec 27, 2022 · Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal …
Paneth cells: Current Biology - Cell Press
WebJun 16, 2014 · Paneth cells, along with goblet cells, enterocytes, tuft cells and enteroendocrine cells, represent the principal cell types of the epithelium of the small …
Paneth Cell - an overview | ScienceDirect Topics
WebLearn about Paneth cells, a secretory epithelial lineage in the small intestine that produces defensins and Wnt ligands. Find out how Paneth cells differentiate, maintain …
Paneth cells: the hub for sensing and regulating intestinal flora
WebPaneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on …
Paneth cells secrete lysozyme via secretory autophagy during
WebJul 27, 2017 · Abstract. Intestinal Paneth cells limit bacterial invasion by secreting antimicrobial proteins, including lysozyme. However, invasive pathogens can disrupt the …
The Paneth Cell: The Curator and Defender of the Immature …
WebApr 3, 2020 · This review will provide an up to date and comprehensive look at Paneth cell ontogeny, the impact Paneth cells have on the host-microbial axis in the immature …
Pathology Outlines - Anatomy & histology
WebOct 29, 2021 · Paneth cells. They have a triangular shape with densely eosinophilic cytoplasmic granules and basally located nuclei, as opposed to enteroendocrine cells …
Paneth cells as a site of origin for intestinal inflammation
WebOct 2, 2013 · We conclude that deletion of Xbp1 specifically in Paneth cells results in unresolved ER stress, UPR activation and induction of autophagy, which can serve as a …
Paneth Cells during Viral Infection and Pathogenesis - PMC
WebApr 26, 2018 · Here, we discuss recent insights into Paneth cell biology, models to study their function, and the impact, both direct and indirect, of Paneth cells on enteric viral …
Paneth cell granule dynamics on secretory responses to bacterial ...
WebFeb 25, 2019 · Abstract. Paneth cells at the base of small intestinal crypts secrete granules containing α-defensins in response to bacteria and maintain the intestinal environment by …
Intestinal Paneth cell differentiation relies on asymmetric
WebNov 24, 2023 · Paneth cells form a major element of the niche microenvironment providing various growth factors to orchestrate intestinal stem cell homeostasis, such as Wnt3. …
Paneth cells constitute the niche for Lgr5 stem cells in intestinal ...
WebNov 28, 2010 · Nature - Paneth cells, specialized cells found in the intestinal epithelium, are known to protect stem cells by producing bactericidal compounds. Now another crucial …
Paneth cells: their role in innate immunity and inflammatory disease
WebPaneth cells were first described over a century ago as granulated cells at the base of the small intestinal “crypts of Lieberkühn”. 20 While their function remained an enigma until …
Cell fate specification and differentiation in the adult ... - Nature
WebSep 21, 2020 · Paneth cells and EECs both derive from shared progenitor cells, slowly dividing label-retaining cells (LRCs). All EEC subtypes are daughter cells of a common …
Stiffness Restricts the Stemness of the Intestinal Stem Cells and …
WebThe large and optically dark Paneth cells (enumerated by 1, 2 and 3) are used as a point of reference. At t=36 hrs, new Paneth cells (marked by black arrows) appear within the …
- Some results have been removed