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Factor XI deficiency in humans - Journal of Thrombosis and …
WEBFactor XI (FXI) deficiency is an autosomal recessive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin. To date, 152 mutations in the FXI gene have been reported with four exhibiting founder effects in specific populations, …
Eighteen unrelated patients with factor XI deficiency, four novel ...
WEBApr 28, 2003 · Patients were diagnosed as factor XI deficient as a result of low or borderline factor XI levels. The majority of patients were referred for the investigation of a bleeding …
Inhibition of factor XI activation attenuates inflammation and ...
WEBMay 17, 2012 · Because activation of the contact proteases factor XII (FXII), prekallikrein, and factor XI (FXI) can trigger coagulation and inflammatory responses, the contact …
- Author: Erik I. Tucker, Norah G. Verbout, Philberta Y. Leung, Sawan Hurst, Owen J. T. McCarty, David Gailani...
- Publish Year: 2012
- Studies of factor xi activity low at 46%
WEBFactor XI (FXI) deficiency is an autosomal reces-sive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin.
Clinical Pharmacology of Factor XI Inhibitors: New Therapeutic ...
WEBOct 26, 2022 · The functional consequence of pharmacologic inhibition of FXI was a significant aPTT prolongation in a dose- and duration-dependent manner following …
Persistently High Levels of Coagulation Factor XI as a Risk …
WEBJul 25, 2023 · Coagulation factor XI (FXI) promotes fibrin formation and inhibits fibrinolysis. Elevated plasma FXI levels, limited to a single measurement, are associated with a …
Clinical Pharmacology of Factor XI Inhibitors: New …
WEBOct 26, 2022 · Particularly, in a systematic review of observational studies in AF, the relative risk reduction for major bleeding with apixaban vs. warfarin was 38%, with dabigatran vs. warfarin 35%, and with …
Factor XI: Hemostasis, Thrombosis, and Antithrombosis
WEBMay 1, 2012 · Recent studies have provided new insight into the molecular structure and functional features of FXI and have demonstrated distinct structural and biological …
Pharmacological targeting of coagulation factor XI …
WEBHuman coagulation factor (F) XI deficiency, a defect of the contact activation system, protects against venous thrombosis, stroke, and heart attack, whereas FXII, plasma prekallikrein, or kininogen deficiencies are …
Turning Up to Eleven: Factor XI Inhibitors as Novel Agents to …
WEBMar 1, 2021 · There exists new interest in factor XI inhibition as novel therapeutic target based on observations of lower thrombotic rates and without significant bleed risk in …
Factor XI Inhibitors: perspectives in primary and secondary
WEBMay 14, 2024 · Factor XI as a new target for prevention of thromboembolism in cardiovascular disease: a meta-analysis of randomized controlled trials. Article 18 May …
Coronary artery stenting in a patient with factor XI deficiency
WEBDec 20, 2011 · Coagulation factors related to prolonged aPTT and normal prothrombin time were measured and a marked decrease of factor XI activity (<3%: normal range …
Factor XI deficiency in humans - SELIGSOHN - 2009 - Journal of ...
WEBJul 13, 2009 · Factor XI (FXI) deficiency is an autosomal recessive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin. To date, 152 …
Detection of Mild Clotting Factor Deficiencies. Critical Role of the ...
WEBDec 3, 2015 · To investigate the suitability of 5 commercially available aPTT reagents to detect mild/moderate deficiencies of clotting factors, we assessed their responsiveness …
The Evolving Dilemma of Factor XI in Pregnancy: Suggestions ...
WEBAbstract. A case of a patient with severe factor XI (FXI) deficiency who presented for her seventh labor and delivery is presented. The nature of FXI deficiency, its prevalence, …
Inhibition of factor XI activation attenuates inflammation and ...
WEBMay 5, 2012 · Activation of the contact protease factor XII (FXII) on negatively charged surfaces, including bacterial components, activates prekallikrein and factor XI (FXI) in …
Safety of the oral factor XIa inhibitor asundexian compared with ...
WEBAsundexian at 20 mg and 50 mg doses lead to reliable suppression of activated coagulation factor XI (FXIa) with once-daily dosing. Asundexian treatment results in significantly …
Pharmacological targeting of coagulation factor XI mitigates the ...
WEBHuman coagulation factor (F) XI deficiency, a defect of the contact activation system, protects against venous thrombosis, stroke, and heart attack, whereas FXII, plasma …
Factor XI deficiency in humans - ScienceDirect
WEBJul 1, 2009 · Factor XI (FXI) deficiency is an autosomal recessive injury-related bleeding tendency, which is common in Jews particularly of Ashkenazi origin.
Factor XI Inhibitors: Potential Role in End-Stage Kidney Disease
WEBNov 1, 2023 · This review article presents the most recent pharmacological data with FXI inhibitors, briefly describes phase 2 and 3 clinical trials with these agents, and critically …
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