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Jan 24, 2023 · Our results support intensive treatment strategies using CD47 inhibitors combined with cytotoxic agents and molecular targeted agents (such as anti-VEGF agents) in CD47 …

CD47 is a representative innate immune checkpoint involved in the evasion of tumor cell phagocytosis by macrophages. This large-scale study comprehensively examined the …

Nov 5, 2024 · CD47 expression in CRC was associated with the activation of several oncogenic pathways and an immune-engaged TME. Our findings may provide valuable information for …

Tumor CD47 expression has been suggested to contribute to immune evasion by tumor cells through the CD47–SIRPA axis. In the present study, 269 advanced CRC lesions were …

Here we describe safety and efficacy data from a Phase 2 microsatellite stable (MSS) colorectal (CRC) expansion cohort in which patients were treated with DSP107 alone or with …

CD47 is a representative innate immune checkpoint involved in the evasion of tumor cell phagocytosis by macrophages. This large- scale study comprehensively examined the …

Mar 4, 2020 · Results: The expression of CD47 was upregulated and correlated to poor prognosis in CRC patients. Functional assays revealed that CD47 promoted CRC cell growth and …

The study by Arai et al1 provides significant insights into the role of CD47 gene expression in colorectal cancer (CRC) and its implications for immunotherapy. The authors present …

CD47 plays an important role in suppressing phagocytosis through binding to transmembrane protein SIRP-alpha on macrophages. Targeting CD47 is a novel strategy for cancer …

Mar 7, 2021 · High tumor CD47 expression (HR = 1.75), lymph node metastasis (HR = 2.26), and peritoneal metastasis (HR = 5.80) were cited as potential independent risk factors. Based on …

In this week’s Journal for ImmunoTherapy for Cancer, Arai and colleagues analyzed next-generation sequencing data for DNA and RNA from 14,287 patients with colorectal cancer …

Regulators of CD47 expression in cancer cells includes cytokines, oncogenes, microRNAs as well as enzymes. IL-6 induces the expression of CD47 through activating STAT3 signaling pathway.

In this study, expression of CD47 was examined by immunostaining in colorectal cancer (CRC) and compared with the expression of CD44, which is a marker for cancer stem cells. In 95 …

cancer (CRC) categorized by median CD47 expression level, and showed that CD47, a key component of innate immunity in deflecting phagocytosis, is associated with molecular …

Refrigeration is acceptable if the serum will be received by the NYGH MSS lab within 1-2 days of collection. NYGH Prenatal Screening Requisition Form should be shipped with the sample.

Hence, Olaparib and 5-FU combination has stronger synergistic cytotoxic effect specifically to MMR deficient MSI CRC, while Olaparib monotherapy may emerge as a maintenance therapy …

To help you understand the accuracy of STS and NIPT, view the type of results that 50,000 people can get if they choose prenatal screening.

When should you consider genetic testing? Genetic testing can be useful at different stages of life. Whether you are planning a family or already pregnant, discovering that a family member has …