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  2. The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) 20, 21, 22, 23 is a risk prediction model that is used to compute the probabilities of carrying rare loss-of-function variants in the breast or ovarian cancer susceptibility genes BRCA1, BRCA2, PALB2, CHEK2, and ATM (referred to as the “major genes”), and to estimate the future risks of developing breast or ovarian cancer.
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    Is Boadicea a risk predictor of breast cancer?Methods: We validated BOADICEA (V.6) in the Swedish KARolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA) cohort including 66 415 women of European ancestry (median age 54 years, IQR 45-63; 816 incident breast cancers) without previous cancer diagnosis.
    Is recurrent hidradenitis linked to breast cancer?
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    Dr. ANUVITHA KAMATH

    MBBS · 3 years of exp

    Hidradenitis suppurativa is a condition in which painful lumps are formed under the skin. It is also known as acne inversa. They are commonly found in the areas where skin rubs against each other such as under the breasts, armpit, groin region, and buttocks. It is developed due to the blockage of hair follicles and is most commonly seen in women. The symptoms of this are blackheads, pea-sized lumps, and leaking painful sores. Recurrent episodes of hidradenitis are linked with higher risks of developing squamous cell carcinoma and lead to breast cancer. But this is seen only in a few cases and not much data is available to associate the increased risk of developing breast cancer.
    Q&A: Hidradenitis Suppurativa
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    How does Boadicea treat breast cancer phenotypes?BOADICEA incorporates tumour phenotypes by treating breast cancer subtypes as different disease end points ( Mavaddat et al, 2010 ). For example, in the case of ER status, breast cancer is divided into ER-negative and ER-positive disease with incidences that depend on the underlying genetic effects.
    How does Boadicea model breast cancer susceptibility?BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast cancer susceptibility genes and a polygenic component, decomposed into an unmeasured and a measured component - the polygenic risk score (PRS). The current version was developed using a 313 SNP PRS.
     
  4. BOADICEA: a comprehensive breast cancer risk prediction model ...

  5. Studies of boadicea breast cancer
  6. BOADICEA: a comprehensive breast cancer risk …

    WEBBreast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm …

  7. BOADICEA: a comprehensive breast cancer risk prediction model ...

  8. Incorporating Alternative Polygenic Risk Scores into the …

  9. Original research: Enhancing the BOADICEA cancer risk …

  10. Comparative validation of the BOADICEA and Tyrer-Cuzick …

  11. BOADICEA breast cancer risk prediction model: updates to …

  12. Prospective validation of the BOADICEA multifactorial breast …

  13. BOADICEA: a comprehensive breast cancer risk prediction model ...

  14. Incorporating alternative Polygenic Risk Scores into the …

  15. CanRisk Tool—A Web Interface for the Prediction of Breast and …

  16. Prospective validation of the BOADICEA multifactorial breast …

  17. About the Calculator: The Breast Cancer Risk Assessment Tool

  18. New breast cancer genes found in women of African ancestry, …

  19. Weighted metrics are required when evaluating the performance …

  20. Incorporating Alternative Polygenic Risk Scores into the …

  21. Mammographic Breast Density and Utility in Breast Cancer

  22. Prospective validation of the BOADICEA multifactorial breast …

  23. Genetic clinicians' confidence in BOADICEA comprehensive …

  24. Breast Cancer Basics | Breast Cancer | CDC - Centers for …