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  2. Fever of unknown origin (FUO) is a high temperature without any known cause after diagnostic tests have been done12345. The causes of FUO can be categorized as any of the following24:
    • Infection: tuberculosis, mononucleosis, Lyme disease, cat scratch fever, endocarditis, and others.
    • Inflammation: lupus, rheumatoid arthritis, inflammatory bowel disease, and others.
    • Malignancy: lymphoma, leukemia, pancreatic carcinoma, and other cancers and sarcomas.
    • Miscellaneous: fevers caused by drug use or abuse, hyperthyroidism, hepatitis, and factors that don’t fit into other categories.
    Collagen vascular diseases, including systemic lupus, rheumatoid arthritis, and scleroderma, are also a major cause of FUO1.
    Learn more:
    Fever of unknown origin (FUO), as its name says, is a high temperature without any known cause after diagnostic tests have been done. What Causes FUO? Three major causes are infections, tumors, and collagen vascular diseases. Collagen-vascular diseases include systemic lupus, rheumatoid arthritis, and scleroderma.
    carle.org/Conditions/Fever-of-unknown-origin

    Causes of FUO can be categorized as any of the following:

    • infection: tuberculosis, mononucleosis, Lyme disease, cat scratch fever, endocarditis, and others
    www.healthline.com/health/fever-of-unknown-origin
    Common causes of FUO include infections, malignancies, noninfectious inflammatory disease (e.g., vasculitides, granulomatous disease, connective tissue diseases), miscellaneous, and undiagnosed 2, 4, 5 (Table 1 6). Lower-income countries typically have higher rates of infection and malignancy as causes of FUO.
    www.aafp.org/pubs/afp/issues/2022/0200/p137.html

    Causes of FUO are usually divided into 4 categories ( see Table: Some Causes of Fever of Unknown Origin (FUO) ):

    • Infections (25 to 50%)
    • Connective tissue disorders (10 to 20%)
    • Neoplasms (5 to 35%)
    www.merckmanuals.com/professional/infectious-di…
    Worldwide, infection is the leading cause of FUO with prevalence varying by country and geographic region. Extrapulmonary tuberculosis is the most frequent cause of FUO. Drug-induced hyperthermia, as the sole symptom of an adverse drug reaction, should always be considered.
    en.wikipedia.org/wiki/Fever_of_unknown_origin
     
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