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- No, Orencia doesn’t cause weight gainNo, Orencia doesn’t cause weight gain. This side effect wasn’t seen during studies of the drug. In fact, nausea is a common side effect of Orencia, and it may reduce your appetite. This could lead to weight loss. If you have unexplained weight changes during your Orencia treatment that concern you, talk with your doctor.www.healthline.com/health/drugs/orencia-side-effects
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