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    Diazirine - Wikipedia

    In organic chemistry, diazirines are a class of organic molecules consisting of a carbon bound to two nitrogen atoms, which are double-bonded to each other, forming a cyclopropene-like ring, 3H-diazirine (>CN2). They are isomeric with diazocarbon groups (>C=N=N), and like them can serve as … See more

    A number of methods exist in the literature for the preparation of diazirines, which begin from a variety of reagents.
    Synthesis from ketones See more

    Diazirines are often used as photoreactive crosslinking reagents, as the reactive carbenes they form upon irradiation with UV light can insert into C-H, N-H, and O-H bonds. This results … See more

    Chemistry image

    Upon irradiation with UV light, diazirines form reactive carbene species. The carbene may exist in the singlet form, in which the two free electrons occupy the same orbital, or the triplet form, … See more

     
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  3. Photoreactive Crosslinker Chemistry | Thermo Fisher Scientific - US

  4. Target Identification by Diazirine Photo-Cross-linking and Click ...

  5. Studies of diazirine
  6. Diazirine - an overview | ScienceDirect Topics

  7. Labeling Preferences of Diazirines with Protein Biomolecules

  8. New Trends in Diaziridine Formation and Transformation (a Review)

  9. Diazirine based photoaffinity labeling - ScienceDirect

  10. Recent Applications of Diazirines in Chemical Proteomics

    WEBNov 15, 2018 · Among the commonly employed photoreactive groups, diazirines have emerged as the gold standard. In this Minireview, recent developments in the field of diazirine-based photoaffinity labeling will …

  11. Fishing for Drug Targets: A Focus on Diazirine …

    WEBApr 23, 2018 · Diazirine-based photoaffinity probes (PAPs) can facilitate the process by covalently capturing transient molecular interactions. This can help identify target proteins and map the ligand’s interactome. …

  12. Overview of diazirine synthesis, activation, and applications. (a ...

  13. Diazirines: Carbene Precursors Par Excellence | Accounts of …

  14. A Genetically Encoded Diazirine Analogue for …

    WEBOct 28, 2019 · We show that site-selective labeling of an RNA-binding protein with a diazirine-based unnatural amino acid gives higher yields of the photo-crosslinking product under milder irradiation conditions.

  15. Structure–function relationships in aryl diazirines reveal optimal ...

  16. Structure–function relationships in aryl diazirines reveal optimal ...

  17. Structure–function relationships in aryl diazirines reveal optimal ...

  18. One-Pot Synthesis of Diazirines and - Wiley Online Library

  19. An Efficient Diazirine‐Based Four‐Armed Cross‐linker for Photo ...

  20. Recent Advances in Chemical Biology Using Benzophenones …

  21. Diazirine | Sigma-Aldrich - MilliporeSigma

  22. New Trends in Diaziridine Formation and Transformation (a Review)

  23. Synthesis and Reactivity of Diazirine-Containing Polymers via ...

  24. Genetically encoded releasable photo-cross-linking strategies for ...

  25. 3H-Diazirine | CH2N2 | CID 78958 - PubChem

  26. Precisely Patterned Channels in a Vertical Organic …