diazirine - Search
  1. Wikipedia
    https://en.wikipedia.org/wiki/Diazirine

    Diazirine - Wikipedia

    CAS Number3H: 157-22-2
    3D model (JSmol)3H: Interactive image
    Beilstein Reference605387
    ChEBI3H: CHEBI:51620
    Diazirine - an overview | Science…
    ScienceDirect
    Labeling Preferences of Diazirine…
    ACS Publications
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  1. Bokep

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  2. Thermo Fisher Scientific
    https://www.thermofisher.com/us/en/home/life...

    Photoreactive Crosslinker Chemistry | Thermo Fisher Scientific - US

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    Genetically encoded protein photocrosslinker with a ... - …
    nature.com
    Photo-crosslinking: An Emerging Chemical Tool for …
    pubmed.ncbi.nlm.nih.gov
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  3. ScienceDirect
    https://www.sciencedirect.com/topics/chemistry/diazirine

    Diazirine - an overview | ScienceDirect Topics

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    Overview of diazirine synthesis, activation, and applications. …
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    New Trends in Diaziridine Formation and Transformation …
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  4. Studies of diazirine
    National Center for Biotechnology Information
    New Trends in Diaziridine Formation and Transformation (a Review)
    This review focuses on diaziridine, a high strained three-membered heterocycle with two nitrogen atoms that plays an important role as one of the most important precursors of diazirine photoaffinity probes, as well as their formation and transformation.
    Author: Zetryana Puter…
    Published: 2021/08
    Publication: Molecules…
    National Center for Biotechnology Information
    Target Identification by Diazirine Photo-Cross-linking and Click Chemistry
    Target identification of biologically active small-molecules is often the rate-determining step in forward chemical genetics. Photo-affinity labeling (PAL) represents a useful biochemical strategy for target identification in complex protein mixtures.
    Author: Andrew L. Mac…
    Published: 2009/12
    DOI: 10.1002/9780470…
    Chemistry Europe
    Recent Applications of Diazirines in Chemical Proteomics
    The elucidation of substrate–protein interactions is an important component of the drug development process. Due to the complexity of native cellular environments, elucidating these fundamental biochemical interactions remains challenging. Photoaffinity
    Author: Matthew W. H…
    Published: 15 Novemb…
    Cited By: 43
    ScienceDirect
    Diazirine based photoaffinity labeling
    Diazirines are among the smallest photoreactive groups that form a reactive carbene upon light irradiation. This feature has been widely utilized in photoaffinity labeling to study ligand–receptor, ligand–enzyme and protein–protein interactions, and in
    Published: 2012/01/15
    Cited By: 0
    Keywords: Diazirine; P…
    National Center for Biotechnology Information
    Structure–function relationships in aryl diazirines reveal optimal design features to maximize C–H insertion†
    Diazirine reagents allow for the ready generation of carbenes upon photochemical, thermal, or electrical stimulation. Because carbenes formed in this way can undergo rapid insertion into any nearby C–H, O–H or N–H bond, molecules that encode diazirine
    Author: Stefania F. Mu…
    Published: 2021/09/09
    Publication: Chem Sci…
    ScienceDirect
    Research Article Understanding diazirine oligomers: A theoretical investigation of solvent effects and molecular properties
    Diazirines have captured significant attention in the scientific community, particularly in the field of biology, owing to their diverse applications. In this study, we explore diazirine oligomers ranging from monomers to pentamers, organized in linear,
    Published: 2024/03/01
    Cited By: 0
    Keywords: Diazirine cl…
    Chemistry Europe
    A Genetically Encoded Diazirine Analogue for RNA–Protein Photo-crosslinking
    Ultraviolent crosslinking is a key experimental step in the numerous protocols that have been developed for capturing and dissecting RNA–protein interactions in living cells. UV crosslinking covalently stalls dynamic interactions between RNAs and the
    Author: Dr. Dmytro Dzi…
    Published: 28 Octobe…
    Cited By: 9
    National Center for Biotechnology Information
    Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors
    The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein–protein,
    Author: Muhammad M…
    Published: 2020/05
    Publication: Molecules…
    PubMed
    New Trends in Diaziridine Formation and Transformation (a Review)
    This review focuses on diaziridine, a high strained three-membered heterocycle with two nitrogen atoms that plays an important role as one of the most important precursors of diazirine photoaffinity probes, as well as their formation and transformation.
    Author: Zetryana Puter…
    Published: 2021/07/26
    Keywords: diaziridines…
  5. ACS Publications
    https://pubs.acs.org/doi/10.1021/jacs.1c02509

    Labeling Preferences of Diazirines with Protein Biomolecules

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348119

    New Trends in Diaziridine Formation and Transformation (a Review)

  7. Explore diazirine

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647699

    Target Identification by Diazirine Photo-Cross-linking and Click ...

  9. Chemistry Europe
    https://chemistry-europe.onlinelibrary.wile…

    Recent Applications of Diazirines in Chemical Proteomics

    WEBNov 15, 2018 · Among the commonly employed photoreactive groups, diazirines have emerged as the gold standard. In this Minireview, recent developments in the field of diazirine-based photoaffinity labeling will …

  10. People also ask
    What is a standard state of diazirine?Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). In organic chemistry, diazirines are a class of organic molecules consisting of a carbon bound to two nitrogen atoms, which are double-bonded to each other, forming a cyclopropene -like ring, 3 H -diazirine ( >CN2 ).

    Diazirine - Wikipedia

    en.wikipedia.org
    Why is diazirine a good reagent?Diazirines are very good precursors for the production of stable carbenes through thermolysis or photolysis. They smoothly insert into C H, N H, and O H bonds and are often used as photoreactive crosslinking reagents due to their smaller size, longer irradiation wavelength, short period of irradiation, and stability toward nucleophiles.

    Diazirine - an overview | ScienceDirect Topics

    sciencedirect.com
    What is diazirine azipentanoate?Diazirines are a newer class of photo-activatable chemical groups that are being incorporated into various kinds of crosslinking and labeling reagents. The diazirine (azipentanoate) moiety has better photostability than phenyl azide groups, and it is more easily and efficiently activated with long-wave UV light (330 to 370 nm).

    Photoreactive Crosslinker Chemistry | Thermo Fisher Scientific - US

    thermofisher.com
    Why are diazirine systems important?Diazirine systems are a major source of carbenes, thus they are used as precursors for many organic and organometallic compounds.

    Diazirine - an overview | ScienceDirect Topics

    sciencedirect.com
    How is diazirine irradiated?UV irradiation of the diazirine generates a carbene intermediate (II) that covalently crosslinks to the protein target (III). The adduct is then detected by conjugation with an azide-containing reporter group under click chemistry conditions (IV).

    Target Identification by Diazirine Photo-Cross-linking and Click

    ncbi.nlm.nih.gov
    What is a diazirine (Daz)?Diazirines (DAZ) are perhaps the smallest of all the PCGs, and this affords them the added advantage of nominal alteration of the properties of the probe into which they have been introduced. This singular feature distinguishes DAZs from other PCGs and has made them very attractive for use in the study of biological processes and interactions.

    Recent Advances in Chemical Biology Using Benzophenones and Diazir…

    ncbi.nlm.nih.gov
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  11. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0968089611005062

    Diazirine based photoaffinity labeling - ScienceDirect

  12. RSC Publishing
    https://pubs.rsc.org/en/content/articlehtml/2021/sc/d1sc03631a

    Structure–function relationships in aryl diazirines reveal optimal ...

  13. ResearchGate
    https://www.researchgate.net/figure/Overview-of...

    Overview of diazirine synthesis, activation, and applications. (a ...

  14. ACS Publications
    https://pubs.acs.org/doi/10.1021/acs.jmedc…

    Fishing for Drug Targets: A Focus on Diazirine …

    WEBApr 23, 2018 · Trifluoromethyl. Abstract. Target identification is a high-priority, albeit challenging, aspect of drug discovery. Diazirine-based photoaffinity probes (PAPs) can facilitate the process by covalently …

  15. ACS Publications
    https://pubs.acs.org/doi/10.1021/acs.macromol.4c00443

    Synthesis and Reactivity of Diazirine-Containing Polymers via ...

  16. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457397

    Structure–function relationships in aryl diazirines reveal optimal ...

  17. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.202100679

    One-Pot Synthesis of Diazirines and - Wiley Online Library

  18. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0925346724000508

    Understanding diazirine oligomers: A theoretical investigation of ...

  19. Chemistry Europe
    https://chemistry-europe.onlinelibrary.wiley.com/...

    A Genetically Encoded Diazirine Analogue for …

    WEBOct 28, 2019 · We chose two diazirine-based pyrrolysine analogues and focused on the iron regulatory protein 1 (IRP1) as a model RNA-binding protein. We studied the effect of the unnatural amino acid mutagenesis …

  20. RSC Publishing
    https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc00974f

    Trifunctional fatty acid derivatives: the impact of diazirine position

  21. ACS Publications
    https://pubs.acs.org/doi/10.1021/ar050155h

    Diazirines: Carbene Precursors Par Excellence | Accounts of …

  22. Nature
    https://www.nature.com/articles/s41586-023-05914-y

    Tracking chromatin state changes using nanoscale photo ... - Nature

  23. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288102

    Recent Advances in Chemical Biology Using Benzophenones …

  24. MilliporeSigma
    https://www.sigmaaldrich.com/US/en/search/...

    Diazirine | Sigma-Aldrich - MilliporeSigma

  25. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34361648

    New Trends in Diaziridine Formation and Transformation (a Review)

  26. MDPI
    https://www.mdpi.com/1420-3049/26/15/4496

    New Trends in Diaziridine Formation and Transformation (a …

  27. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11118520

    Trifunctional fatty acid derivatives demonstrate the impact of ...