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  2. Graft-versus-host disease


    Graft versus host disease (GVHD) is an immune-mediated condition resulting from a complex interaction between donor and recipient adaptive immunity.
    emedicine.medscape.com

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    The pathophysiology of graft versus host disease is complex. GVHD is the result of a series of complex interactions between the immune cells of the donor (the graft) and the host tissues; the disease is most likely to occur after a transplantation procedure...

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    What is graft versus host disease (GVHD)?Access free multiple choice questions on this topic. Graft-versus-host disease (GvHD) is a systemic disorder that occurs when the graft's immune cells recognize the host as foreign and attack the recipient’s body cells. “Graft” refers to transplanted, or donated tissue, and “host” refers to the tissues of the recipient.
    What is graft versus host disease?Graft versus host disease, or GVHD, is a complication of a stem cell transplant, a treatment for blood cancers and certain blood or immune system disorders. With GVHD, white blood cells called T cells from the donor -- the graft, or the “G” in GVHD -- attack cells within the recipient’s, or host’s, body.
    Do B cells play a role in graft versus host disease (GVHD)?The successful use of B-cell–targeted therapy such as rituximab in chronic GVHD has sparked an interest in defining the role of B cells in the pathophysiology of GVHD. [ 17] Interactive factors involved in the pathogenesis of graft versus host disease (GVHD.) Courtesy of Romeo A. Mandanas, MD, FACP.
    What is the difference between GVHD and host hematopoietic stem cell transplant?“Graft” refers to transplanted, or donated tissue, and “host” refers to the tissues of the recipient. It is a common complication after allogeneic hematopoietic stem cell transplant (HCT) . GVHD has been classically classified based on the timing of presentation into acute and chronic using a cutoff of 100 days post-transplant.
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