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  2. Conserved Domain-based Prediction (CDPred) is a computational algorithm that is designed to theoretically calculate the effect of substituting an amino acid relative to the reference sequence within functional modules - the protein domains.
    research.nhgri.nih.gov/software/CDPred/
    CDD uses a simple mechanism to assign high confidence to matches between protein query sequences and domain models.
    academic.oup.com/nar/article/41/D1/D348/1071484
     
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