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  2. These zero-calorie sweeteners might not help people lose weight, and experts postulate that artificial sweeteners may trigger inflammation and alter normal metabolism, the gut microbiome, and blood vessels in ways that promote type 2 diabetes, unhealthy cholesterol levels, and high blood pressure.
    www.health.harvard.edu/heart-health/sugar-substit…
    But some studies have found that sucralose might not be so great for those tiny helpers. Research in rodents shows that sucralose upsets the microbiome balance, and that can lead to increased inflammation. “We know long-term inflammation can contribute to a variety of problems, including obesity and diabetes,” says Patton.
    health.clevelandclinic.org/is-sucralose-splenda-ba…

    Since the introduction of artificial sweeteners (AS) to the North American market in the 1950s, a growing number of epidemiological and animal studies have suggested that AS may induce changes in gut bacteria and gut wall immune reactivity, which could negatively affect individuals with or susceptible to chronic inflammatory conditions such as inflammatory bowel disease (IBD), a disorder that has been growing exponentially in...

    www.frontiersin.org/articles/10.3389/fnut.2021.7462…
     
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