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- The serotonin transporter (SERT) is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron12. This process, known as serotonin reuptake, terminates the action of serotonin and recycles it in a sodium-dependent manner1.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner.en.wikipedia.org/wiki/Serotonin_transporterSERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake.www.wikiwand.com/en/Serotonin_transporter - People also ask
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See all on WikipediaThe serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin … See more
Studies on the serotonin transporter have combined neuroimaging and genetics methods, e.g., a voxel-based morphometry study found less grey matter in perigenual anterior cingulate cortex See more
The distribution of the serotonin transporter in the brain may be imaged with positron emission tomography using radioligands called … See more
Wikipedia text under CC-BY-SA license WebJul 28, 2016 · Serotonin transporters (SERTs) are largely recognized for one aspect of their function—to transport serotonin back into the presynaptic terminal after its release. …
- Author: Louis J. De Felice
- Publish Year: 2016
WebLearn about the serotonin transporter (SERT), a protein that regulates serotonin levels in the brain and is involved in various neuropsychiatric disorders. Find out how SERT is …
WebNov 4, 2019 · Abstract. Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action …
WebApr 6, 2016 · The serotonin transporter (SERT) terminates serotonergic signalling through the sodium- and chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target for...
WebApr 11, 2019 · The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the...
WebAug 28, 2007 · One key regulator is the serotonin transporter (5-HTT), which removes serotonin released into the synaptic cleft. The 5-HTT protein is encoded by a single gene, SLC6A4.
WebApr 19, 2016 · Researchers determined the 3-D structure of the serotonin transporter and visualized how 2 common antidepressants interact with the protein. The findings provide insights for designing new ways to target …
Structures and membrane interactions of native serotonin …
WebThe serotonin transporter (SERT) removes serotonin from synaptic, perisynaptic, and other extracellular regions by harnessing the energy from sodium and chloride transmembrane …
Serotonin Transporter - an overview | ScienceDirect Topics
WebThe serotonin transporter (SERT) is a 12-transmembrane protein that mediates serotonin uptake (back into the neuron) and thus reduces extracellular serotonin levels in the brain …
Serotonin transporter: gene, genetic disorders, and ... - PubMed
WebThe highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin …
Serotonin: What Is It, Function & Levels - Cleveland Clinic
WebSerotonin is a chemical that carries messages between nerve cells, telling your body how to perform various functions. Serotonin plays a role in mood, digestion and sleep.
The Serotonin Transporter Gene and Depression - Psychology …
WebMay 13, 2019 · The gene most commonly associated with depression is the serotonin transporter gene SLC6A4 (Bleys et al., 2018). Serotonin is a neurotransmitter affecting …
Serotonin transporters - PubMed
WebThe serotonin transporter is most well known as the site of action of the serotonin reuptake inhibitors, which were initially developed as antidepressants, but now are the most …
Serotonin transporter–ibogaine complexes illuminate …
WebApr 24, 2019 · The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium- and chloride-dependent recycling of serotonin into presynaptic …
5-HTTLPR - Wikipedia
Web5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene that codes for …
Structure-based discovery of conformationally selective inhibitors …
WebMay 2, 2023 · The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, …
Selective serotonin reuptake inhibitor - Wikipedia
WebSelective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and …
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