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- Oligonucleotides are short DNA or RNA molecules that have a wide range of applications in genetic testing, research, and forensics12. They are oligomers, meaning they are made up of a few nucleotides1. Oligonucleotides are used in a variety of applications, including gene expression analysis, gene synthesis, and antisense therapy1.
Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.en.wikipedia.org/wiki/OligonucleotideLast updated February 24, 2024 • 7 min read From Wikipedia, The Free Encyclopedia Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.wikimili.com/en/Oligonucleotide - People also ask
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See all on WikipediaOligonucleotide - Wikipedia
Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics. Commonly made in the laboratory by solid-phase chemical synthesis, these small fragments of nucleic acids can be manufactured as single-stranded molecules with … See more
Oligonucleotides are chemically synthesized using building blocks, protected phosphoramidites of natural or chemically modified nucleosides or, to a lesser extent, of non-nucleosidic compounds. The … See more
Creating chemically stable short oligonucleotides was the earliest challenge in developing ASO therapies. Naturally occurring … See more
Cell uptake/internalisation still represents the biggest hurdle towards successful oligonucleotide (ON) therapeutics. A straightforward … See more
• Aptamers, oligonucleotides with important biological applications
• Morpholinos, oligos with non-natural backbones, which do … See more1981The first solid-phase chemical synthesis of oligonucleotides is reported by H. Gobind Khorana and coworkers1990sAntisense oligonucleotides are developed as potential therapeutic agents for genetic diseases1993The first DNA microarray is invented by Patrick O. Brown and David Botstein2006Janet Heasman uses Morpholino antisense oligonucleotides to knock down genes in vertebrates2016The first FDA-approved Morpholino drug, eteplirsen, is launched for the treatment of Duchenne muscular dystrophyAntisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of See more
Chromatography
Alkylamides can be used as chromatographic stationary phases. Those phases have been investigated for the separation of … See more• Spingler B (January 2012). "Chapter 3. Metal-Ion-Promoted Conformational Changes of Oligonucleotides". In Sigel A, Sigel H, Sigel RK (eds.). Interplay between metal ions and nucleic acids. Vol. 10. Springer Science & Business Media. pp. 103–118. See more
Wikipedia text under CC-BY-SA license What is an Oligonucleotide? - News-Medical.net
WEBJul 20, 2023 · Oligonucleotides are short nucleic acid polymers used in research, genetic testing and forensics. Oligonucleotides are usually …
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- Studies of Oligonucleotides wikipedia
Oligonucleotide Synthesis - an overview | ScienceDirect Topics
WEBThe use of therapeutic oligonucleotides (TONs) has become a major alternative to treat disease thanks to recent advances in oligonucleotide synthesis and delivery …
Allele-specific oligonucleotide - Wikipedia
WEBAn allele-specific oligonucleotide ( ASO) is a short piece of synthetic DNA complementary to the sequence of a variable target DNA. It acts as a probe for the presence of the target …
Oligonucleotide Therapeutics: From Discovery and Development …
WEBJan 22, 2022 · Oligonucleotides are a class of single- or double-stranded small synthetic nucleic acid polymers (≈20-mer) that can be used to modulate gene expression [ 2 ]. In …
Oligonucleotide - an overview | ScienceDirect Topics
WEBOligonucleotides are short synthetic DNA or RNA polymers, which modulate gene expression through Watson-Crick base pairing with targeted nucleic acids.47, 48 ONTs …
Oligonucleotide Therapies: The Past and the Present - PMC
WEBAug 1, 2015 · The early development of synthetic oligonucleotides. T he landmark discovery of DNA as the hereditary material by Avery et al. in 1944, 1 followed by the …
Advancements in the characterisation of …
WEBApr 10, 2022 · Share. Abstract. The first oligonucleotide therapeutic was approved by the Food and Drug Administration in 1998, and since then, 12 nucleic acids have been commercialised as medicines. To be approved, …
A Brief History of Oligonucleotide Synthesis - Springer Nature
WEBJulian Barnes wrote A History of the World in 10 1/2 Chapters (1). Oligonucleotides on this score warrant at most a comma, a literary augenblick, but lacking the skill of the …
Oligonucleotide - an overview | ScienceDirect Topics
WEB1 Theory. Oligonucleotides are synthesized by the addition of one base at a time, extending from the 3′ to the 5′-end, attached to a solid-phase support. When the …
Therapeutic Oligonucleotides: An Outlook on Chemical Strategies …
WEBSep 11, 2023 · Introduction. Oligonucleotide therapeutics are synthetically modified nucleic acids that can modulate gene expression via a range of processes, including RNA …
Oligonucleotide Standards | Biologics - US Pharmacopeia (USP)
WEBUSP Biologics™. Synthetic oligonucleotides are an emerging class of therapeutics that target diseases by mediating RNA functions. Oligonucleotides have already …
Oligonucleotide Therapeutics: From Discovery and Development …
WEBNov 26, 2021 · Oligonucleotides are a class of single- or double-stranded small synthetic nucleic acid polymers (≈20-mer) that can be used to modulate gene expression [ 2 ]. In …
IUPAC - oligonucleotides (O04287)
WEBFeb 24, 2014 · Source: PAC, 1995, 67, 1307.(Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations …
Oligonucleotide - an overview | ScienceDirect Topics
WEBOligonucleotides are small molecules 8–50 nucleotides in length that bind via Watson-Crick base pairing to enhance or repress the expression of target RNA. The use of …
Antisense Oligonucleotides: Basic Concepts and Mechanisms
WEBMar 1, 2002 · Oligonucleotides are unmodified or chemically modified single-stranded DNA molecules. In general, they are relatively short (13–25 nucleotides) and hybridize …
Chemical Synthesis of Oligonucelotide Sequences: …
WEBOligonucleotides are used in a variety of molecular biology techniques, from next-generation sequencing to genetic testing. Maintaining the sequence fidelity of synthetic …
Perspectives on the Designation of Oligonucleotide Starting …
WEBMar 25, 2021 · The designation of starting materials (SMs) for pharmaceuticals has been a topic of great interest and debate since the first ICH quality guidance was published. The …
Oligonucleotidase - Wikipedia
WEBarticles. PubMed. articles. NCBI. proteins. Oligonucleotidase ( EC 3.1.13.3, oligoribonuclease) is an exoribonuclease derived from Flammulina velutipes. [1] This …
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