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    • National Center for Biotechnology Information
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834788

      The retinaldehyde reductase DHRS3 is essential for preventing …

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      DHRS3, a retinal reductase, is differentially regulated by …
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      Dhrs3 Protein Attenuates Retinoic Acid Signaling and Is …
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      What chromosome is DHRS3 in neuroblastoma?The DHRS3 gene maps to a region of human chromosome 1 at band p36.1 ( 15 ), which is frequently lost in aggressive neuroblastoma tumors ( 3 ).

      DHRS3, a retinal reductase, is differentially regulated by retinoic acid an…

      ncbi.nlm.nih.gov
      How is DHRS3 induced in neuroblastoma cells?DHRS3 expression was reported to be induced by retinoids in neuroblastoma cell lines ( 3) and in naïve CD4 + T cells ( 19) and by the retinoid X receptor (RXR) rexinoid ligand bexarotene in MMTV-erbB2 mice ( 23) and to be responsive to serum concentration in normal and transformed human buccal keratinocytes ( 39 ).

      DHRS3, a retinal reductase, is differentially regulated by retinoic acid an…

      ncbi.nlm.nih.gov
      How do DHRS3 and CYP26A1 protect against rheumatoid arthritis (RA)?As demonstrated during embryonic development ( 12 ), DHRS3 and CYP26A1 may act defensively to protect against a buildup of RA in hepatocytes, where both are expressed. As in THP-1 cells, DHRS3 mRNA expression in the liver of RA-treated vitamin A-adequate rats was upregulated by RA.

      DHRS3, a retinal reductase, is differentially regulated by retinoic acid an…

      ncbi.nlm.nih.gov
      Where is DHRS3 expressed?A) DHRS3 is expressed at high levels in fetal liver, kidney (k), nasal epithelium (n), along the sternum (st) and the spinal cord (sc), and the limb (arrow) of WT embryos. Moderate immunoreactivity staining is observed in the cerebellum (Cb), the developing pituitary (pit), and the telencephalic choroid plexus (TCh).

      The retinaldehyde reductase DHRS3 is essential for preventing the form…

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    • Journal of Biological Chemistry
      https://www.jbc.org/article/S0021-9258(20)57550-9/fulltext

      p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein …

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      DHRS3, a retinal reductase, is differentially regulated by retinoic ...

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