ENaC is located in the apical membrane of polarized epithelial cells in particular in the kidney (primarily in the collecting tubule), the lung, the skin, the male and female reproductive tracts … See more

The epithelial sodium (Na ) channel (ENaC) family belongs to the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-d structures and are homologous. See more

Expression of ENaC in mammalian cell cultures is cytotoxic, resulting in sodium uptake, cell swelling and cell death, complicating production of stable cell lines to study ENaC. … See more

ENaC consists of three different subunits: α, β, γ. All three subunits are essential for transport to the membrane assembly of functional channels on the membrane. The C-terminus of each … See more

Members of the epithelial Na channel (ENaC) family fall into four subfamilies, termed alpha, beta, gamma and delta. The proteins exhibit the same apparent topology, each with … See more

The exon–intron architecture of the three genes encoding the three subunits of ENaC have remained highly conserved despite the … See more

ENaC interaction with CFTR is of important pathophysiological relevance in cystic fibrosis. CFTR is a transmembrane channel responsible for chloride transport and defects in this … See more