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- Cyclotides are bioactive peptides from plants that are characterized by their head-to-tail cyclic backbone and knotted arrangement of their three conserved disulfide bonds. Their natural function is thought to be as host defense agents and a single plant can express dozens to hundreds of cyclotides.Author: David J. CraikPublish Year: 2015
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Cyclotide - Wikipedia
WebCyclotide. In biochemistry, cyclotides are small, disulfide -rich peptides isolated from plants. [1] . Typically containing 28-37 amino acids, they are characterized by their head-to-tail cyclised peptide backbone and the interlocking arrangement of their three disulfide bonds.
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Cliotide - Wikipedia
WebCliotides are a group of related peptides that have been isolated from the heat-stable fraction of Clitoria ternatea (Cliotides) extracts. [1] Cliotides belong to a larger classification of peptides, the cyclotides .
Cyclotides: Overview and biotechnological applications - PMC
WebCyclotides are globular microproteins with a unique head-to-tail cyclized backbone, stabilized by three disulfide bonds forming a cystine knot. The present review provides an overview on cyclotides and their applications as molecular imaging agents and peptide …
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Cyclotides: From Structure to Function | Chemical Reviews
WebThis Review explores the class of plant-derived macrocyclic peptides called cyclotides. We include an account of their discovery, characterization, and distribution in the plant kingdom as well as a detailed analysis of their sequences and structures, biosynthesis and …
Discovery, structure, function, and applications of cyclotides ...
WebCyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and three conserved disulphide bonds that form a cyclic cystine knot motif.
Cyclotides: Overview and Biotechnological Applications
WebCyclotides are globular microproteins with a unique head-to-tail cyclized backbone, stabilized by three disulfide bonds forming a cystine knot.
Cyclotide - an overview | ScienceDirect Topics
WebThe cyclotide family consists of multi-functional cyclic peptides with approximately 29 amino acid residues and a typical cysteine knot motif, showing an extremely conserved disulfide bonding pattern (Cys I –Cys IV, Cys II –Cys V, and Cys III –Cys VI). Cyclotides can be …
Overview on the Discovery and Applications of Cyclotides
WebCyclotides are bioactive peptides from plants that are characterized by their head-to-tail cyclic backbone and knotted arrangement of their three conserved disulfide bonds. Their natural function is thought to be as host defense agents and a single plant can express …
Cyclotide - an overview | ScienceDirect Topics
WebCyclotides are plant host-defense peptides that have a wide range of biological activities and have diverse potential applications in medicine and agriculture. These 27–37 amino acid peptides have a head-to-tail cyclic backbone and are built around a cystine knot core, …
Cyclotides: Plant Defense Toxins | SpringerLink
WebCyclotides are plant-derived miniproteins that are exceptionally stable and have a wide range of biological activities, with their principal function thought to be in plant defense. Their putative defense-related activities include insecticidal, anthelmintic, molluscicidal, …
Production of bioactive cyclotides: a comprehensive overview
WebCyclotides are an emerging class of disulfide-rich plant cyclic peptides, believed to be present in plants for defence purposes. Their exceptional thermal, chemical and enzymatic stabilities make them suitable as therapeutic agents, agrochemicals, molecular imaging …
Cycloid - Wikipedia
WebIn geometry, a cycloid is the curve traced by a point on a circle as it rolls along a straight line without slipping. A cycloid is a specific form of trochoid and is an example of a roulette, a curve generated by a curve rolling on another curve.
Cyclotides: From Gene Structure to Promiscuous Multifunctionality
WebThe cyclotides are a family of cyclic peptides that range between 28 and 37 amino acid residues and are commonly found in plant species from the Violaceae, Rubiaceae, Curcubitaceae, Poaceae, and Fabaceae families. 1 – 4 This protein group is …
Chemical and biological production of cyclotides - PMC
WebCyclotides are fascinating naturally occurring micro-proteins (≈30 residues long) present in several plant families, and display various biological properties such as protease inhibitory, anti-microbial, insecticidal, cytotoxic, anti-HIV and hormone-like activities.
Cyclotides: From Structure to Function - PubMed
WebCyclotides: From Structure to Function. Chem Rev. 2019 Dec 26;119 (24):12375-12421. doi: 10.1021/acs.chemrev.9b00402. Epub 2019 Dec 12. Authors. Simon J de Veer 1 , Meng-Wei Kan 1 , David J Craik 1. Affiliation. 1 Institute for Molecular Bioscience , The University of …
Cyclotide host-defense tailored for species and environments
WebCyclotides are cyclic peptides produced by plants. Due to their insecticidal properties, they are thought to be involved in host defense. Violets produce complex mixtures of cyclotides, that...
Frontiers | Cyclotide Evolution: Insights from the Analyses of Their ...
WebCyclotides are a family of plant proteins that are characterized by a cyclic backbone and a knotted disulfide topology. Their cyclic cystine knot (CCK) motif makes them exceptionally resistant to thermal, chemical, and enzymatic degradation.
Cyclotide Structure–Activity Relationships: Qualitative and ...
WebCyclotides are a family of plant-derived proteins that are characterized by a cyclic backbone and a knotted disulfide topology. Their cyclic cystine knot (CCK) motif makes them exceptionally resistant to thermal, chemical, and enzymatic degradation.
The involvement of cyclotides in mutual interactions of ... - Nature
WebCyclotides are cyclic peptides involved in host-plant defenses. A single Viola sp. can produce more than a hundred cyclotides with different biological activities and roles. The organ and tissue...
シクロチド - Wikipedia
Webシクロチド (Cyclotides) は、植物に含まれる 環状ペプチド の一群である [1] 。 28-37 アミノ酸 からなり、C末端とN末端が結合して環状となっていることが特徴である。 また、分子内に3つの ジスルフィド結合 を持つ。 これらの特徴はまとめて環状 シスチンノット …
Cyclic peptide - Wikipedia
WebCyclic peptides can be classified according to the types of bonds that comprise the ring. Homodetic cyclic peptides, such as cyclosporine A, are those in which the ring is composed exclusively of normal peptide bonds (i.e. between the alpha carboxyl of one residue to …
Gloeospermum - Wikipedia
WebGenus: Gloeospermum. Triana & Planch. Gloeospermum is a plant genus in the Violaceae family. [1] It has been found in Central American, including Panama, and Ecuador. [2] [3] Species include: Gloeospermum boreale C.V.Morton. Gloeospermum crassicarpum.
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