In vertebrates, the master circadian clock is contained within the suprachiasmatic nucleus (SCN), a bilateral nerve … See more

Evidence for a genetic basis of circadian rhythms in higher eukaryotes began with the discovery of the period (per) locus in Drosophila melanogaster from forward genetic screens completed by Ron Konopka and … See more

For a long time, it was thought the transcriptional activation/repression cycles driven by the transcriptional regulators constituting the circadian clock was the main driving force for circadian gene expression … See more

The autoregulatory feedback loops in clocks take about 24 hours to complete a cycle and constitute a circadian molecular clock. This generation of the ~24-hour molecular clock is governed by post-translationa… See more

Circadian oscillators are simply oscillators with a period of approximately 24 hours. In response to light stimulus, the body corresponds with a system and network of pathways that work together to determine the biologic… See more

Modern experimental approaches using systems biology have identified many novel components in biological clocks that suggest an integrative view on how organisms maintain circadian oscillation.
Recently, B… See more

While a precise 24-hour circadian clock is found in many organisms, it is not universal. Organisms living in the high arctic or high antarctic do not experience solar time in all seasons, though most are believed to … See more