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See all on WikipediaAntisense therapy - Wikipedia
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content … See more
The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense … See more
Half-life and stability
ASO-based drugs employ highly modified, single-stranded chains of synthetic nucleic acids that … See moreCurrent clinical trials
As of 2020 more than 50 antisense oligonucleotides were in clinical trials, including over 25 in advanced clinical trials (phase II or III).
Phase III trials
A follow-on drug to … See moreAugust 1998Fomivirsen was approved by the U.S. FDA as a treatment for cytomegalovirus retinitis.January 2013Mipomersen was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.December 2016Nusinersen received regulatory approval from FDA and soon after, from other regulatory agencies worldwide.May 2019Volanesorsen was approved by the European Medicines Agency for the treatment of familial chylomicronaemia syndrome.October 2018Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis.2019Milasen was approved by the FDA for the treatment of Batten disease.2020Eteplirsen, golodirsen, and viltolarsen received FDA approval for the treatment of cases that can benefit from skipping exon 51 or 53 of the dystrophin transcript.2023Tofersen was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis
Tofersen (marketed as Qalsody) was approved by the FDA for the treatment of SOD1- associated See moreWikipedia text under CC-BY-SA license Antisense RNA - Wikipedia
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein. The asRNAs (which occur naturally) have been found in both prokaryotes and eukaryotes, and can …
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 11 mins
Oligonucleotide - Wikipedia
WEBAntisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of antisense RNA they prevent …
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- Studies of Antisense wikipedia
Antisense technology: an overview and prospectus - Nature
WEBMar 24, 2021 · Nature Reviews Drug Discovery - Antisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Here, Crooke and colleagues …
Antisense RNA: the new favorite in genetic research - PMC
WEBDec 6, 2017 · Antisense RNAs are unique DNA transcripts. They are small, noncoding, and diffusible molecules, containing 19–23 nucleotides that complement mRNA. With the …
Antisense technology: an overview and prospectus - PubMed
WEBAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs …
Antisense Therapy in Neurology - PMC - National Center for ...
WEBAug 2, 2013 · Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged …
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Antisense technology: A review - Journal of Biological Chemistry
WEBTen RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double-strand ASOs (siRNAs) have now been approved for commercial use, and the ASOs in phase 2/3 trials are innovative, delivered by multiple routes of administration and focused on both rare and common diseases.
WEBMar 24, 2021 · Antisense technology is a drug discovery platform based on short chemically modified oligonucleo-tides (12–24-mers) that bind to their RNA targets by …
Antisense - National Human Genome Research Institute
WEB5 days ago · Antisense is the non-coding DNA strand of a gene. In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the …
Antisense Drugs Make Sense for Neurological Diseases - PMC
WEBJan 1, 2021 · The genetic basis for most inherited neurodegenerative diseases has been identified, yet there are limited disease modifying therapies for these patients. A new …
Antisense oligonucleotides: the next frontier for treatment of
WEBDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein …
Gapmer - Wikipedia
WEBGapmers are short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence. These linear pieces of genetic information are designed to …
DNA - Wikipedia
WEBOne proposal is that antisense RNAs are involved in regulating gene expression through RNA-RNA base pairing. A few DNA sequences in prokaryotes and eukaryotes, and …
Antisense technology: A review - ScienceDirect
WEBJan 1, 2021 · “Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is …
Antisense RNA Therapeutics: A Brief Overview. - PMC
WEBNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS …
Antisense - an overview | ScienceDirect Topics
WEBAntisense oligos are short (∼20 mer) synthetic single-stranded molecules, analogues of natural nucleic acids, which inhibit or modulate gene expression.
Antisense therapy for cancer | Nature Reviews Cancer
WEBMay 20, 2005 · Antisense oligonucleotides offer one approach to target genes involved in cancer progression, especially those that are not amenable to small-molecule or …
The powerful world of antisense oligonucleotides: From bench to …
WEBMar 31, 2020 · Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical …
Antisense Therapy - an overview | ScienceDirect Topics
WEBAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single …
Gene regulation by antisense transcription | Nature Reviews …
WEBNov 12, 2013 · Antisense transcription, which was initially considered by many as transcriptional noise, is increasingly being recognized as an important regulator of gene …
Inotersen - Wikipedia
WEBInotersen, sold under the brand name Tegsedi, is a 2'-O- (2-methoxyethyl) (2'-MOE) antisense oligonucleotide medication used for the treatment of nerve damage in adults with hereditary transthyretin-mediated amyloidosis.
Antisense Oligonucleotides: An Emerging Area in Drug Discovery …
WEBJun 26, 2020 · Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO …
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