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Antisense therapy - Wikipedia
WEBAntisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre …
See results only from en.wikipedia.orgAntisense RNA
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense …
Sense (molecular biology)
The other strand of the double-stranded DNA molecule is referred to as negative …
Sense strand
In genetics, a sense strand, or coding strand, is the segment within double …
Oligonucleotide
Antisense oligonucleotides (ASO) are single strands of DNA or RNA that are …
Antisense technology: an overview and prospectus - Nature
WEBNine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use,...
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Antisense oligonucleotides: the next frontier for treatment of
WEBAntisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein expression through several distinct...
Antisense technology: A review - Journal of Biological Chemistry
WEBXue-Hai Liang. Brenda F. Baker. Rosanne M. Crooke. Open Access Published: February 15, 2021 DOI: https://doi.org/10.1016/j.jbc.2021.100416. Antisense technology: A review. Antisense technology is beginning to deliver on the broad promise of the technology.
Antisense RNA: the new favorite in genetic research - PMC
WEBAntisense RNAs represent a specific type of ncRNA used for regulating genetic activity at multiple levels in cells, such as at DNA, RNA and chromosome structures, transcription and translation, and RNA and protein stabilities (Rusk, 2015 ). Antisense RNAs are unique DNA transcripts.
WEBAntisense technology is a drug discovery platform based on short chemically modified oligonucleo-tides (12–24-mers) that bind to their RNA targets by Watson–Crick base pairing10–13. Before ...
Antisense technology: an overview and prospectus - PubMed
WEBAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use, includi …
Antisense Therapy: An Overview | IntechOpen
WEBREGISTER TO DOWNLOAD FOR FREE. Advertisement. Abstract. Nucleic acids are the backbone of antisense therapy. Antisense oligonucleotide-based therapeutics involves downregulation of gene expression.
Antisense - an overview | ScienceDirect Topics
WEBAntisense oligonucleotides are small fragments of DNA that can form complementary pairs with a target mRNA. Intracellularly, the oligo and mRNA hybrid is cleaved by an enzyme, ribonuclease H (RNAse H).
Antisense RNA Therapeutics: A Brief Overview. - PMC
WEBNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS-CoV-2. Another type of nucleic acid therapeutics is antisense oligonucleotides, versatile tools that can be used in multiple ways to target pre-mRNA and mRNA.
The powerful world of antisense oligonucleotides: From bench to …
WEBAbstract. Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the backbone structure of ASOs have transformed them into true approved and commercialized drugs.
Gene regulation by antisense transcription | Nature Reviews …
WEBAntisense expression can coordinate gene expression either in cis or in trans. Their ability to interact with other regulatory mechanisms emphasizes their different but complementary role...
Antisense Therapy - an overview | ScienceDirect Topics
WEBAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single-stranded DNA sequences engineered to be complementary to the specific ‘sense’ (5' to 3') orientation of mRNA coding for the targeted protein.
Antisense Oligonucleotides: An Emerging Area in Drug Discovery …
WEBAntisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO field is an emerging area of drug development that targets the disease source at the RNA level and offers a promising alternative to therapies targeting downstream processes.
Antisense technology: A review - ScienceDirect
WEB“Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is used to refer to ss ASOs, and siRNA refers to ds ASOs that act via AGO2 to cause degradation of target RNAs (for review see ( 13 , 14 )).
DNA - Wikipedia
WEBBoth sense and antisense sequences can exist on different parts of the same strand of DNA (i.e. both strands can contain both sense and antisense sequences). In both prokaryotes and eukaryotes, antisense RNA sequences are produced, but the functions of these RNAs are not entirely clear.
Antisense therapy for cancer | Nature Reviews Cancer
WEBAn antisense oligonucleotide (ASO) is a single-stranded, chemically modified DNA-like molecule that is 17–22 nucleotides in length and designed to be complementary to a selected gene's mRNA and...
The Application of Antisense Technology to Medicine - PMC
WEBAntisense technology is a formidable tool for investigating physiologic and pathologic processes. In addition, it is soon likely to become a mainstay of therapy, particularly in infectious diseases, with wider applications in the future as gene therapy techniques are developed further.
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