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- Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein.
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See all on WikipediaAntisense therapy - Wikipedia
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content … See more
The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense oligonucleotides. See more
Half-life and stability
ASO-based drugs employ highly modified, single-stranded chains of synthetic nucleic acids that achieve wide tissue distribution with very long half-lives. For instance, many ASO-based drugs contain phosphorothioate … See moreCurrent clinical trials
As of 2020 more than 50 antisense oligonucleotides were in clinical trials, including over 25 in See moreAugust 1998Fomivirsen was approved by the U.S. FDA as a treatment for cytomegalovirus retinitis.January 2013Mipomersen was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.December 2016Nusinersen received regulatory approval from FDA and soon after, from other regulatory agencies worldwide.May 2019Volanesorsen was approved by the European Medicines Agency for the treatment of familial chylomicronaemia syndrome.October 2018Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis.2019Milasen was approved by the FDA for the treatment of Batten disease.2020Eteplirsen, golodirsen, and viltolarsen received FDA approval for the treatment of cases that can benefit from skipping exon 51 or 53 of the dystrophin transcript.2023Tofersen was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis
Tofersen (marketed as Qalsody) was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis (ALS) … See moreWikipedia text under CC-BY-SA license Antisense RNA - Wikipedia
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein. The asRNAs (which occur naturally) have been found in both prokaryotes and eukaryotes, and can …
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 11 mins
Antisense technology: an overview and prospectus - Nature
WEBMar 24, 2021 · Nature Reviews Drug Discovery - Antisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Here, Crooke and colleagues …
- Author: Stanley T Crooke, Brenda F Baker, Rosanne M Crooke, Xue-Hai Liang
- Publish Year: 2021
Oligonucleotide - Wikipedia
WEBAntisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of antisense RNA they prevent …
Antisense RNA: the new favorite in genetic research - PMC
WEBDec 6, 2017 · Antisense RNAs are unique DNA transcripts. They are small, noncoding, and diffusible molecules, containing 19–23 nucleotides that complement mRNA. With the …
Antisense technology: an overview and prospectus - PubMed
WEBAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs …
Antisense technology: A review - Journal of Biological …
WEBTen RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double-strand ASOs (siRNAs) have now been approved for commercial use, and the ASOs in phase 2/3 trials are innovative, …
Antisense Therapy: An Overview | IntechOpen
WEBFeb 12, 2019 · The major therapeutic approach to target RNA-based therapy is antisense oligonucleotides because of their high affinity, selectivity, ease of chemical modifications, and less toxicity. This …
Antisense Therapy in Neurology - PMC - National Center for ...
WEBAug 2, 2013 · Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged …
Antisense therapy for cancer | Nature Reviews Cancer
WEBMay 20, 2005 · Antisense oligonucleotides offer one approach to target genes involved in cancer progression, especially those that are not amenable to small-molecule or antibody inhibition.
Antisense Therapy - an overview | ScienceDirect Topics
WEBAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single …
Antisense oligonucleotides: the next frontier for treatment of
WEBDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein …
Frontiers | Antisense Oligonucleotide: Basic Concepts and …
WEBMar 28, 2019 · An antisense oligonucleotide (ASO) is a single-stranded deoxyribonucleotide, which is complementary to the mRNA target. The goal of the …
Sense (molecular biology) - Wikipedia
WEBSome alternative antisense structural types have been experimentally applied as antisense therapy. In the United States, the Food and Drug Administration (FDA) has …
Antisense - an overview | ScienceDirect Topics
WEBAntisense oligos are short (∼20 mer) synthetic single-stranded molecules, analogues of natural nucleic acids, which inhibit or modulate gene expression.
The Application of Antisense Technology to Medicine - PMC
WEBAntisense technology is a formidable tool for investigating physiologic and pathologic processes. In addition, it is soon likely to become a mainstay of therapy, particularly in …
The powerful world of antisense oligonucleotides: …
WEBMar 31, 2020 · Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the …
Antisense RNA Therapeutics: A Brief Overview - PubMed
WEBNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS …
Antisense technology: A review - ScienceDirect
WEBJan 1, 2021 · “Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is …
Sense strand - Wikipedia
WEBThe sense strand is the strand of DNA that has the same sequence as the mRNA, which takes the antisense strand as its template during transcription, and eventually undergoes …
Antisense Oligonucleotides: An Emerging Area in Drug Discovery …
WEBJun 26, 2020 · Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO …
Antisense transcription as a tool to tune gene expression
WEBJan 13, 2016 · A synthetic system developed in Escherichia coli and a computational model provide mechanistic insights into antisense transcription and show that it is a reliable …
Inotersen - Wikipedia
WEBInotersen, sold under the brand name Tegsedi, is a 2'-O- (2-methoxyethyl) (2'-MOE) antisense oligonucleotide medication used for the treatment of nerve damage in adults …
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