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See all on WikipediaAntisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content … See more
The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense oligonucleotides. See more
Half-life and stability
ASO-based drugs employ highly modified, single-stranded chains of synthetic nucleic acids that achieve wide tissue distribution with very long half … See moreCurrent clinical trials
As of 2020 more than 50 antisense oligonucleotides were in clinical trials, including over 25 in See moreAugust 1998Fomivirsen was approved by the U.S. FDA as a treatment for cytomegalovirus retinitis.January 2013Mipomersen was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.December 2016Nusinersen received regulatory approval from FDA and soon after, from other regulatory agencies worldwide.May 2019Volanesorsen was approved by the European Medicines Agency for the treatment of familial chylomicronaemia syndrome.October 2018Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis.2019Milasen was approved by the FDA for the treatment of Batten disease.2020Eteplirsen, golodirsen, and viltolarsen received FDA approval for the treatment of cases that can benefit from skipping exon 51 or 53 of the dystrophin transcript.2023Tofersen was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis
Tofersen (marketed as Qalsody) was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis (ALS) … See moreWikipedia text under CC-BY-SA license 
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein. The asRNAs (which occur naturally) have been found in both prokaryotes and eukaryotes, and can …
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 11 mins
WEBMar 24, 2021 · Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use,...
- Author: Stanley T Crooke, Brenda F Baker, Rosanne M Crooke, Xue-Hai Liang
- Publish Year: 2021
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WEBThe other strand of the double-stranded DNA molecule is referred to as negative-sense (also negative (−) or antisense), and is reverse complementary to both the positive-sense strand and the RNA transcript.
WEBXue-Hai Liang. Brenda F. Baker. Rosanne M. Crooke. Open Access Published: February 15, 2021 DOI: https://doi.org/10.1016/j.jbc.2021.100416. Antisense technology: A review. Antisense technology is beginning to …
WEBDec 6, 2017 · Antisense RNAs represent a specific type of ncRNA used for regulating genetic activity at multiple levels in cells, such as at DNA, RNA and chromosome structures, transcription and translation, and RNA and protein stabilities (Rusk, 2015 ). Antisense RNAs are unique DNA transcripts.
WEBJan 1, 2021 · A new class of drugs - antisense oligonucleotides (ASOs) - are showing promise as a therapeutic platform for treating neurological diseases. ASOs are designed to bind to the RNAs encoded by a target gene, thereby suppressing expression by catalyzing degradation of those RNAs or to elevate expression by correcting faulty RNA splicing.
WEBAug 2, 2013 · Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged as an exciting and promising strategy for the treatment of various neurodegenerative and neuromuscular disorders.
WEBMay 23, 2024 · Antisense is the non-coding DNA strand of a gene. In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. Narration. Antisense. …
WEBAntisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content modulation through splicing site binding on pre-mRNA.
Antisense therapy for cancer | Nature Reviews Cancer
WEBMay 20, 2005 · An antisense oligonucleotide (ASO) is a single-stranded, chemically modified DNA-like molecule that is 17–22 nucleotides in length and designed to be complementary to a selected gene's mRNA and...
Gene regulation by antisense transcription | Nature Reviews …
WEBNov 12, 2013 · Antisense expression can coordinate gene expression either in cis or in trans. Their ability to interact with other regulatory mechanisms emphasizes their different but complementary role...
Antisense Therapy - an overview | ScienceDirect Topics
WEBAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single-stranded DNA sequences engineered to be complementary to the specific ‘sense’ (5' to 3') orientation of mRNA coding for the targeted protein.
Antisense technology: an overview and prospectus - PubMed
WEBAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use, includi …
Gapmer - Wikipedia
WEBGapmers are short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence. These linear pieces of genetic information are designed to hybridize to a target piece of RNA and silence the gene through the …
WEBMar 24, 2021 · Antisense technology is a drug discovery platform based on short chemically modified oligonucleo-tides (12–24-mers) that bind to their RNA targets by Watson–Crick base pairing10–13. Before ...
Antisense RNA Therapeutics: A Brief Overview. - PMC
WEBNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS-CoV-2. Another type of nucleic acid therapeutics is antisense oligonucleotides, versatile tools that can be used in multiple ways to target pre-mRNA and mRNA.
Antisense technology: A review - ScienceDirect
WEBJan 1, 2021 · “Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is used to refer to ss ASOs, and siRNA refers to ds ASOs that act via AGO2 to cause degradation of target RNAs (for review see ( 13 , 14 )).
Sense strand - Wikipedia
WEBIn genetics, a sense strand, or coding strand, is the segment within double-stranded DNA that carries the translatable code in the 5′ to 3′ direction, and which is complementary to the antisense strand of DNA, or template strand, which does not carry the translatable code in the 5′ to 3′ direction. [1] The sense strand is the strand of ...
Antisense oligonucleotides: the next frontier for treatment of
WEBDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein expression through several distinct...
The powerful world of antisense oligonucleotides: …
WEBMar 31, 2020 · Abstract. Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the …
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Oligonucleotide - Wikipedia
WEBAntisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of antisense RNA they prevent protein translation of certain messenger RNA strands by binding to them, in a …
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