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WEBMar 24, 2021 · Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have …
- Author: Stanley T Crooke, Brenda F Baker, Rosanne M Crooke, Xue-Hai Liang
- Publish Year: 2021
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WEBDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein expression through several distinct...
WEBDec 6, 2017 · Antisense RNAs represent a specific type of ncRNA used for regulating genetic activity at multiple levels in cells, such as at DNA, RNA and chromosome …
WEBXue-Hai Liang. Brenda F. Baker. Rosanne M. Crooke. Open Access Published: February 15, 2021 DOI: https://doi.org/10.1016/j.jbc.2021.100416. Antisense technology: A review. Antisense technology is beginning to …
WEBMar 24, 2021 · Antisense technology is a drug discovery platform based on short chemically modified oligonucleo-tides (12–24-mers) that bind to their RNA targets by …
WEBAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs …
WEBMar 31, 2020 · Abstract. Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the …
Antisense Therapy: An Overview | IntechOpen
WEBFeb 12, 2019 · REGISTER TO DOWNLOAD FOR FREE. Advertisement. Abstract. Nucleic acids are the backbone of antisense therapy. Antisense oligonucleotide-based therapeutics involves downregulation of gene …
Antisense - an overview | ScienceDirect Topics
WEBAntisense oligonucleotides are small fragments of DNA that can form complementary pairs with a target mRNA. Intracellularly, the oligo and mRNA hybrid is cleaved by an enzyme, …
Antisense Therapy - an overview | ScienceDirect Topics
WEBAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single …
Gene regulation by antisense transcription | Nature Reviews …
WEBNov 12, 2013 · Antisense expression can coordinate gene expression either in cis or in trans. Their ability to interact with other regulatory mechanisms emphasizes their …
Antisense Oligonucleotides: An Emerging Area in Drug Discovery …
WEBJun 26, 2020 · Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO …
DNA - Wikipedia
WEBBoth sense and antisense sequences can exist on different parts of the same strand of DNA (i.e. both strands can contain both sense and antisense sequences). In both …
Antisense RNA Therapeutics: A Brief Overview. - PMC
WEBNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS …
Antisense technology: A review - ScienceDirect
WEBJan 1, 2021 · “Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is …
Antisense therapy for cancer | Nature Reviews Cancer
WEBMay 20, 2005 · An antisense oligonucleotide (ASO) is a single-stranded, chemically modified DNA-like molecule that is 17–22 nucleotides in length and designed to be …
The Application of Antisense Technology to Medicine - PMC
WEBAntisense technology is a formidable tool for investigating physiologic and pathologic processes. In addition, it is soon likely to become a mainstay of therapy, particularly in …
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