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See all on WikipediaAntisense therapy - Wikipedia
Antisense therapy is a form of treatment that uses antisense oligonucleotides (ASOs) to target messenger RNA (mRNA). ASOs are capable of altering mRNA expression through a variety of mechanisms, including ribonuclease H mediated decay of the pre-mRNA, direct steric blockage, and exon content … See more
The common stem for antisense oligonucleotides drugs is -rsen. The substem -virsen designates antiviral antisense oligonucleotides. See more
Half-life and stability
ASO-based drugs employ highly modified, single-stranded chains of synthetic nucleic acids that achieve wide tissue distribution with very long half … See moreCurrent clinical trials
As of 2020 more than 50 antisense oligonucleotides were in clinical trials, including over 25 in See moreAugust 1998Fomivirsen was approved by the U.S. FDA as a treatment for cytomegalovirus retinitis.January 2013Mipomersen was approved by the FDA for the treatment of homozygous familial hypercholesterolemia.December 2016Nusinersen received regulatory approval from FDA and soon after, from other regulatory agencies worldwide.May 2019Volanesorsen was approved by the European Medicines Agency for the treatment of familial chylomicronaemia syndrome.October 2018Inotersen received FDA approval for the treatment of hereditary transthyretin-mediated amyloidosis.2019Milasen was approved by the FDA for the treatment of Batten disease.2020Eteplirsen, golodirsen, and viltolarsen received FDA approval for the treatment of cases that can benefit from skipping exon 51 or 53 of the dystrophin transcript.2023Tofersen was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis
Tofersen (marketed as Qalsody) was approved by the FDA for the treatment of SOD1- associated amyotrophic lateral sclerosis See moreWikipedia text under CC-BY-SA license Antisense RNA - Wikipedia
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein. The asRNAs (which occur naturally) have been found in both prokaryotes and eukaryotes, and can …
Wikipedia · Text under CC-BY-SA license- Estimated Reading Time: 11 mins
Antisense technology: an overview and prospectus - Nature
WEBMar 24, 2021 · Nature Reviews Drug Discovery - Antisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Here, Crooke and colleagues describe the key technological...
- Author: Stanley T Crooke, Brenda F Baker, Rosanne M Crooke, Xue-Hai Liang
- Publish Year: 2021
- Studies of Antisense wikipedia
Oligonucleotide - Wikipedia
WEBAntisense oligonucleotides (ASO) are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of antisense RNA they prevent protein translation of certain messenger RNA strands by binding to them, in a …
Antisense technology: an overview and prospectus - PubMed
WEBAntisense technology is now beginning to deliver on its promise to treat diseases by targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing four chemical classes, two mechanisms of action and four routes of administration have been approved for commercial use, includi …
Antisense RNA: the new favorite in genetic research - PMC
WEBDec 6, 2017 · Antisense RNAs are unique DNA transcripts. They are small, noncoding, and diffusible molecules, containing 19–23 nucleotides that complement mRNA. With the development of antisense RNAs, their application will gradually replace traditional technology for gene-specific silencing.
Antisense Therapy: An Overview | IntechOpen
WEBFeb 12, 2019 · Abstract. Nucleic acids are the backbone of antisense therapy. Antisense oligonucleotide-based therapeutics involves downregulation of gene expression.
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WEBMar 24, 2021 · REVIEWS. Antisense technology: an overview and prospectus. Stanley T. Crooke , Brenda F. Baker , Rosanne M. Crooke and Xue-hai Liang. Abstract | Antisense technology is now beginning to deliver...
Antisense Therapy in Neurology - PMC - National Center for ...
WEBAug 2, 2013 · Antisense therapy is an approach to fighting diseases using short DNA-like molecules called antisense oligonucleotides. Recently, antisense therapy has emerged as an exciting and promising strategy for the treatment of various neurodegenerative and neuromuscular disorders.
Antisense therapy for cancer | Nature Reviews Cancer
WEBMay 20, 2005 · Key Points. Antisense oligonucleotides (ASOs) offer one approach to target genes involved in cancer progression, particularly those that are not amenable to small-molecule or antibody inhibition....
Antisense Drugs Make Sense for Neurological Diseases - PMC
WEBJan 1, 2021 · A new class of drugs - antisense oligonucleotides (ASOs) - are showing promise as a therapeutic platform for treating neurological diseases. ASOs are designed to bind to the RNAs encoded by a target gene, thereby suppressing expression by catalyzing degradation of those RNAs or to elevate expression by correcting faulty RNA splicing.
DNA - Wikipedia
WEBOne proposal is that antisense RNAs are involved in regulating gene expression through RNA-RNA base pairing. A few DNA sequences in prokaryotes and eukaryotes, and more in plasmids and viruses, blur the distinction between sense and antisense strands by having overlapping genes.
Antisense technology: A review - ScienceDirect
WEBJan 1, 2021 · “Antisense” included an oligonucleotide of any structure or chemistry designed to bind target RNA via Watson–Crick hybridization. In practice, antisense is used to refer to ss ASOs, and siRNA refers to ds ASOs that act via AGO2 to cause degradation of target RNAs (for review see (13, 14)).
Antisense - an overview | ScienceDirect Topics
WEBAntisense oligos are short (∼20 mer) synthetic single-stranded molecules, analogues of natural nucleic acids, which inhibit or modulate gene expression.
Antisense RNA Therapeutics: A Brief Overview. - PMC
WEBNucleic acid therapeutics is a growing field aiming to treat human conditions that has gained special attention due to the successful development of mRNA vaccines against SARS-CoV-2. Another type of nucleic acid therapeutics is antisense oligonucleotides, versatile tools that can be used in multiple ways to target pre-mRNA and mRNA.
Antisense oligonucleotides: the next frontier for treatment of
WEBDec 1, 2017 · Antisense oligonucleotides (ASOs) are short, synthetic, single-stranded oligodeoxynucleotides that can alter RNA and reduce, restore, or modify protein expression through several distinct...
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The powerful world of antisense oligonucleotides: …
WEBMar 31, 2020 · Antisense oligonucleotides (ASOs) represent a new and highly promising class of drugs for personalized medicine. In the last decade, major chemical developments and improvements of the …
Gene regulation by antisense transcription | Nature Reviews …
WEBNov 12, 2013 · Antisense expression can coordinate gene expression either in cis or in trans. Their ability to interact with other regulatory mechanisms emphasizes their different but complementary role...
Antisense Oligonucleotides: An Emerging Area in Drug Discovery …
WEBJun 26, 2020 · Antisense oligonucleotides (ASOs) bind sequence specifically to the target RNA and modulate protein expression through several different mechanisms. The ASO field is an emerging area of drug development that targets the disease source at the RNA level and offers a promising alternative to therapies targeting downstream processes.
Antisense Therapy - an overview | ScienceDirect Topics
WEBAntisense therapy involves downregulation of gene expression by complementary oligonucleotide binding to target mRNA. Antisense oligonucleotides are short single-stranded DNA sequences engineered to be complementary to the specific ‘sense’ (5' to 3') orientation of mRNA coding for the targeted protein.
Antisense - Wikipedia
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Sense (molecular biology) - Wikipedia
WEBSome alternative antisense structural types have been experimentally applied as antisense therapy. In the United States, the Food and Drug Administration (FDA) has approved the phosphorothioate antisense oligonucleotides fomivirsen (Vitravene) [5] and mipomersen (Kynamro) [6] for human therapeutic use.
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